177 Comments

I pray every night this is not true. Almost everyone I know and love is vaccinated.

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same here. and none of my jabbed loved ones is open to this information.

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Same here. :-(

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That's the truly frightening part. The ones I know are okay with shunning and discrimination against the unvaxxed like me. Makes it hard to give a care about them. At some point one just ends up exhausted and pissed off at everyone doing it. I'd never wish ill on others as that's just bad karma but I just can't care anymore. Not even for family and friends.

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Not only have we been through a nightmare of resisting these shots now we pray there is no nightmare ahead for those we love who have gotten them. . Is this the 2 faced devil?

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Miracles please for the vaccinated 🙏💜🙏💜🙏💜

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maybe there will be better vaccines that actually work

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No trust for their quackery from me EVER. That horse kicked down the barn doors and flew the coop a looong time ago.

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Love your mixed metaphors 🤩

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He-he! Thank you! I was channeling my inner Yogi Berra. :0))

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Yogi Twain

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Against a fast mutating virus with animal resevoirs? No. That is like playing Whack-A-Mole while drunk, on ludes and blind folded. That was stated 2 years ago and it is still true.

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Same here-I call these thoughts my Viktor Frankl moments.

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Same. Scary.

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Well like everything else Geert Vanden Boscche says, it's NOT true. So lucky you I guess.

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"How will healthy unvaccinated people deal with variants potentiating ADE in vaccinees?"

You addressed the risk to the unvaccinated who've had prior mild infection. What is the risk of ADE to those who've never been exposed and have no innate immune training?

Thanks.

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The unvaxxed will fare much better. The vaccines stimulate adaptive/acquired antibodies with a very limited target -- iirc, just a few epitopes on 1 subunit of the 2-subunit spike.

Natural immunity starts with the innate (ie inborn) system -- everything from skin, mucus & tears to various white blood cells, IgA & IgM antibodies, various biochemicals, and more. Only if that system is overwhelmed, it calls on the adaptive system, which develops antibodies that target all epitopes on the spike *and the nucleocapsid (the protective shell around the genetic payload).

The spike is the part of the virus that mutates, which is why the vax antibodies lose effectiveness.

Because it provides structure, the nucleocapsid is much more stable, or the virus would fall apart. So antibodies targeting tbe structure continue to be effective even as the spike mutates.

That is also why developing a vaccine that targeted only a small part of the mutagenic part of the virus was, frankly, criminally insane. The failure was baked in by design.

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I like your view. The failure was truely inherent by design. I highlighted this design flaw in one of my article on herd immunity.

More insights on https://victorazodoh.substack.com

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Here is what I understand from Dr VB in this and past writings.

The best situation for unvaccinated folks at this time is a history of moderate covid disease that produced a good immune system response that trained their immune system for the next variants. 👍🏼

If an unvaccinated person has history of mild or no disease, their immune system will not have any pre-recognition/ previous training to fight a variant, so the health of their immune system (good food, etc) is important in fighting the virus for the first time.

If a variant arises that has low severity, like current omicron, people who are not vaccinated, with healthy immune systems and no prior covid infection, will handle that variant well, as they are current Omicron.

There may be a variant where vaccinated people have a harder time with severe disease than even unvaccinated people with no prior covid infection. This would be because the vaccine messed up their immune system, and now their immune system can't fight even milder covid variants (due to antibody dependent enhancement, original antigenic sin from the vaccine), or other infections for that matter (because the vaccine, in simple terms, turned off parts of their immune system and they never turned back on, reducing the effectiveness/ dysregulating their immune system. We are seeing this already with multiple Omicron infections in the vaccinated, and cases of shingles and herpes that their immune system would normally keep in check without symptoms).

If a variant arises that has a higher severity (especially if a lot of people keep taking vaccines that pressure the virus to mutate in unexpected ways), both unvaccinated and vaccinated people will be harder hit by this more severe variant. Unvaccinated people with prior covid infection, and their pre-trained immune system, would have an easier time fighting this variant then unvaccinated people with no prior infection (unless it is a bioweapon unrelated to previous covid variants). So again it's so important to be healthy, eat good food, reduce stress so our immune systems are as healthy as possible!

And of course have therapeutics on hand through all of these variants. 👍🏼

I think it's also important to be a psychologically healthy as possible, in order to tolerate what is already happening to our vaccinated loved ones, and what may come in the future. Let's make new friends and connections in addition to our old ones, and form a loving healthy communities that will be a support for our fear and grief, and help us survive and thrive through this period of human history. 💜

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Glad I got the original nuclear power Wuhan strain and was sick for a month!

Immune system is strong!

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Excellent, good for you! 💪🏽❤️

I may have just had the wimpy omicron, I'm not sure. 😄

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Hugs and prayers! You got this. The mind is very powerful and part of the immune system!

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I don't what I got in January, omicron or delta. If it was the former it certainly wasn't wimpy for me. It was rough (no hospital though) and I'm lean, fit and was taking recommended supplements and iodine nasal rinse. It could be something genetic or just that I got a huge viral load (likely from a double vaxxed and masked fellow Californian). I did get get some treatment from an "alternative" doc, if you get my drift but that was after a week already (and mostly for some bronchitis). Anyway, I like to point out that covid isn't necessarily risk-free or pleasant even if you're in great apparent health. However, I made my decision not to get transfected so I would get a broader immune response so I don't regret it despite the unpleasantry but earlier treatment would have probably made it milder and shorter. Oh well, it's done now. Water under the bridge.

What irks me is that the notion that these treatments (FLCCC etc) don't work. Well, if someone uses them and then gets better (that includes avoiding longer-term symptoms) what does that mean? If the treatments work then the denial or discrediting of them is a crime in my book. On the other hand if they don't actually work but the person recovers just the same then it shows the immune system can handle covid just fine so why on Earth would that person need a "vaccine"in the first place.

As for the repetitive 'safe and effective' spiel: Statistically, getting covid seems as "safe" for most (especially with appropriate supplements and treatment) as these transfections do and it's clearly more effective in the long run. Sure getting covid may not be fun or as quick/easy as getting 'the jab' (assuming you're lucky enough to avoid negative side effect of those) but you have to take into consideration the long term issues and given the unknowns there, people are pretending that the transfection chickens aren't coming home to roost....

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had u taken ginger, you would have recoverd in days

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And black seed oil.

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How could anyone not have some immunity to corona viruses? We know that Vid D, zinc, Vitamin C and Quercetin are a good start for prevention. Early tx’s with repurposed drugs as recommended by FLCCC. Anyone know the accuracy of the Oxford T spot tests? I tested negative despite travel, flights, no mask, crowded conditions over 2 1/2 years. The only people we now know with covid, all triple jabbed. Also know over twenty family and friends with severe AE’s two have died.

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Right, I think a lot of people have some immunity to coronaviruses. That may or may not translate well to sars cov2 if it was made in a lab.

I know two unvaccinated people who had mild to moderate Omicron, and they said It felt different than other illnesses they've had, which is why they attributed it to Omicron. They didn't get tested.

Wow, sorry about all your family and friends with severe AE's. 😓 I know a few myself, both family and friends, and it continues to show up more and more. Unfortunately I think this is the only thing that has potential to open their eyes.

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Yes, I’m 69 and wondering if I should try to catch Omicron now, plus whether I should take ivermectin first or wait until there are some real symptoms. In other words, is the degree of natural immunity you develop directly proportional to how sick you got?

Also, Dr. VB, do you think people who are asymptomatic are spreading the virus, whether vaxxed, unvaxxed, not going to develop symptoms, or going to develop them? The “mainstream” position, I believe, is that people are most infectious in the day or two before they develop symptoms.

While I think use of the word “sinners” is a bit off the mark and counterproductive, thank you so much for what I feel is your unique and truly stellar contribution to the world at this time.

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Be aware that taking Ivermectin prior to trying to get infected may frustrate your plans to get infected.

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Dr. Geert did notspeak of „sinners“? He speaks of „Antigenic sin“, this is something completely different. I try to find his explanation for this manifestation and then send it to you. Maybe you can also try to google the term „antigenic sin“, I am sure you will find some explanation.

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"Original Antigenic Sin" is a popular nickname for "immune priming." Immune priming states that the 1st of a kind virus you see is imprinted on your immune memory. In the case of covid vaxes, they imprint the alpha spike (the initial variant) in your immune memory. Every time it sees a similar spike it calls up antibodies designed to fit the alpha variant. That's why the immunity "wears off" with subsequent variants. The antibodies are an increasingly poor fit for the remodeled spikes.

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Actually he did, see the last paragraph.

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Creating this bioweapon is a sin, no?

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I don't believe in the concept of sin, unless you define it as foolishness. Nobody can help being the way they are, defined as separate individuals (which I don't think we are, see Alan Watts) we all act in accordance with our experience and beliefs, which we cannot choose. You can change someone's behavior by making them see things they aren't yet seeing clearly, but accusing them of immoral behavior is only likely to make them defensive and less open to what you're trying to tell them. JMO.

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Yes. I think he was making sone wordplay.

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I found it! Sorry that I did not see it and thus misunderstood you.

Actually he should have called them “criminals”, they know exactly what they are doing, trying to force us directly or indirectly to take the jab.

By “them” I mean big pharma and the governments they working with.

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He did also call it “the unforgivable sin” and “the deadliesst sin ever” when talking about vaccinating children.

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I cannot find it, would you please copy/paste for me?

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Yes, sinners is a bit off the mark...I prefer the word demons.

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sir, take ginger.

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I was about to ask this same question!

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Feb 17, 2022·edited Feb 17, 2022

Me too! Would also like to know why I can't seem to catch covid despite multiple significant exposures. Antibody tests say I haven't had it yet and I've had no symptoms.

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If your innate system was capable of dealing with the virus due to lower viral load or previous mild exposure there would be no need for it to progress to an adaptive response. Be happy with that. From what I understand, in the case of a natural adaptive response (where specific antibodies are created) there is additional learning of the innate system and tcell stimulation that does not occur in these vaccinations. So it's broader and likely more capable of adapting to variants. Basically the broader the response can remain while defeating a viral infection, the better.

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I think a majority of people with healthy immune systems so far can handle it without symptoms, or without major symptoms. I guess it depends in part on the amount of virus you are exposed to, and how your innate immune system fights it off. For some reason, some unvaccinated people get major symptoms. Maybe that has to do with a combination of how much virus they're exposed to and the state of their immune system at the time.

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Correct. It is only if the innate system is overwhelmed that the adaptive/acquired immunity, with highly specific IgG antibodies, kicks in.

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Feb 18, 2022·edited Feb 19, 2022

Not sure about that. Part of the immune system is some nodes in the gut (Peyers Patches) that grab swallowed viruses and develop templates for both the innate and adaptive immune system. If i heard it correctly from this talk with Prof.Robert Clancy: https://www.youtube.com/watch?v=FPPnyzvO7J4

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Possibly, but that still depends on you swallowing enough to make it through the stomach. Plus they contain innate immunity cells(eg macrophages), which will again be 1st responders.

"Peyer’s patches contain a variety of immune cells, including macrophages, dendritic cells, T cells, and B cells. There are also specialized cells, called M cells, next to your Peyer’s patches. These M cells feed antigens to the macrophages and dendritic cells of your Peyer’s patches."

https://www.healthline.com/health/peyers-patches

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I'd read that somewhere but have never seen it confirmed. I do have an extremely strong immune system that i take good care of!

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Yes in would love some clear answers on this kind of question. I’m unvaxxed and had omicron.

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That's one more reason to keep stocked up on therapeutics like ivermectin/black seed oil/vitamin d3 etc.

This lab concocted flu could have been reduced to a whimper if WORKING and CHEAP therapeutics had been allowed from the get-go instead of letting people DIE and pushing the nasty cl0t-sh0t.

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use ginger.

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How much? Fresh ginger?

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Always fresh ginger - dried ginger is useless, except for flavour.

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No need to write pig latin my friend. This is substack, you can speak freely.

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Yeah but 'cl0t sh0t' is 1337. ;p

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The shots are "Safe and Effective" my friend. They're not clot-shot!

You behave like a Human 1.0. You're now in the New World Order designed for Humans 2.0. Welcome to the Covid Zone!!!

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Ha! Do I get a disco in my casket?! ;p

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None of those "therapeutics" have any therapeutic effect whatsoever.

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Who died and made you the Grand Poobah of high upper butt crack?

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Fortunately, ADE doesn't actually exist.

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I live in California so I know many people who have just about lived in a cave for 2 years. 🥴 Luckily I found a unvaccinated community, and my vaccinated adult son's, willing to go about living our lives.

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I have had to have a lot of stupid antigen tests due to being unvaxxed and also did one antibody blood test.. everything had come up negative. I have also been exposed to a few people who had the virus at the time I met them... must be my pure blood :)

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🥂 cheers to our pure blood exceptional immunity!

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I get the message behind this post but it’s difficult to understand. Please could you do a video with diagrams ( along the lines of Dr Been on YouTube and Odysee) to make it easier to fully understand for those of us with medical degrees but not a PhD in Immunology!

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Feb 17, 2022·edited Feb 17, 2022

This has always been the case. I've contacted his team to try and emphasise the need to make these more easy to understand. I can't bring myself to send this to friends as they won't understand. I am honestly not trying to be a prick but I passed the mensa exam at uni (a mate got 2 for 1!) but I just find it almost impossible to easily discern what geert is saying. They need someone with a scientific background but with English as first language and more than that, with a natural ability to communicate in written form.

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The messaging problem is real.

Compare it with the blunt (lying) instrument used by Fauci and Co. "Safe and effective" over and over.

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I think diagrams might help as well. Or even simple animated slides.

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He needs a good technical writer.

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Go to his Twitter page - there a many short videos that are easy to follow.

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Wonderful!!! THANK YOU!

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In his episode discussing GVB’s work, Del Bigtree (Highwire) explains it in a language anyone can understand, using props such as Ken dolls and pompoms. Hilarious but effective.

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Oh my gosh!!! I was thinking that EXACT same thing. Those diagrams help SO SO MUCH!!

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My daughter is in grad school and applied for 50 summer internships and she was rejected because she wasn’t vaccinated. No one would respect her religious exemption. She was anxious and depressed. She got vaccinated with the J&J. I begged her not to get vaccinated and to wait but weekly Covid screening and job rejection was affecting her mental health. She got vaccinated 2 weeks ago. She got an internship, too. I pray everyday that she won’t get sick from the vaccine.

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Why are us companies discriminating against people who, choose to decline an experimental biological still in trial with little safety data and no efficacy? This really does not make sense.

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Dr. Vanden Bossche has come through for us again with solid evidence-data, advice, life saving information for ourselves and our children. Dr. Vanden Bossche is arguably the world's top authority on this matter. His extremely complex argumentation has the ring of truth, and high level expertise. Contrast this with Fauci, "Get the shot, get boosted," ad infinitum, ad nauseaum.

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Fauci is a quack and has never been a scientist in the first place. Only the blind can trust him.

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Vanden Bossche is the quack. He's been wrong about everything.

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Faucian C-19 Allergic and Infectious Dogmas

.

 Natural Immunity doesn’t matter! O no, sometimes it does - It depends on the audience.

 SARS-Cov-2 originated from a bat zoonotic jump. Cannot come from a lab.

 Read my lips – I never funded gain-of-function research.

 The virus fears locked down individuals!

 A 25µm mask can stop 1µm viruses!

 2 x 25µm masks are better!

 3 x 25µm masks are best!

 No, use KN95 instead!

 Asymptomatic transmission has been proven!

 Early treatments don’t work – wait for quackcines..

 The virus knows that 6 feet is a no go zone!

 A glass fence between cubes at the work place prevents the virus from circulating!

 Leaky quackcines can be used to control a scamdemic – Immunology 101!

 Quackcines are Safe and Effective… Repeat this mantra 24/7 and they’ll work for you!

 Antibodies in the blood stream can stop infection in your airways – Follow the Science!

 Booster shots targeting a virus that disappeared in early 2021 can shoot dead Omicron in 2022!

 Using the same booster every quarter will control all future variants…

 Original Antigenic Sin (OAS) is nonsense!

 I did not patent SARS-CoV-2 gp120 HIV insertion - Your cancer-killing T cells are safe…

 I am always right. I am the infallible Prophet of Science!

 Cognitive Dissonance is Appreciated by NIAID

Source: NIAID (Novel Inquisition for Allergic and Infectious Dogmas)

.

Crime Minister Ceaușescu

 Prophet Fauci is a genius!

 We follow the Science in Canadastan!

 Canadastan has already ordered 440 million doses – enough for 10 shots per citizen.

 We’ll control this virus hopefully before our 10th quarterly booster shot!

https://trudeauknows.ca/

.

Dr. Red Pill

 So, 2 weeks to flatten the curve has now become 24 months + 8 future quarters in Canadastan?

.

Fauci

 Follow the science and shut up!

.

Dr. Red Pill Fact Check

 They make sh$t!

https://librti.com/page/view-video?id=1438

https://librti.com/page/view-video?id=1515

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Congratulations, you're a psychopath.

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Fauci knows nothing, learns nothing of the science. We know this from Scott Atlas, who repeatedly ran up against the brick wall of Fauci's and Birx's willful ignorance while on the task force. However, he is a masterful communicator. He keeps it ultra simple and radiates maximal confidence and self-belief. Goebbels would have been green with envy.

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Scott Atlas is a buffoon who knows less than nothing about virology but thinks he's an expert.

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Feb 17, 2022·edited Feb 17, 2022

Geert, thank you once again for your insight and detailed explanation. As a retired scientist, I constantly ponder the lack of attention and understanding your information is being given and ask out loud, too many times, "what is wrong with these people that they don't get it ?" I have grave concerns for those who receive blood transfusion from well meaning vaccinated individuals and what the possible future effects will be to those who receive the gifted blood. I commend you in your persistence in attempting to educate. You are a true hero.

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And all went WRONG around the world this time. When I see the US Secretary of Defense who's double vaxxed, boostered and triple masked getting infected with OMicron, I wonder how these organizations are scientifically managed. As an individual I had a clear scientific evidence back in March 2021 that these gene therapies were not designed to work (they were designed to FAIL!!!). How in the hell could governments around the world with myriads of human resources fail to see under the hood that the injections were fakes?

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From what I hear and see and search for, your predictions of more subsequent early deaths and susceptibility to other diseases is being seen right now by pathologist around the globe from the vaccinated who have passed, they are seeing very strange things in tissue samples, yet again any platform of media is denied. Innate immune systems are being eroded by these prototype vaccines.

I have struggled to understand the erroneous actions of many talented Phd , doctors, media and politicians, to be so polar opposite on pathways yet even when the data is showing one side is incorrect they do not see, are unwilling to see, or listen, my alarm bells are set to ringing loudly, as to why?

Then I can only conclude there is an ulterior motive to their continued dogmatic approach and that is totally scary, as what your eluding to Dr Geert I do believe we are on the cusp of a billion deaths or more.

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Always so brilliant , as it should be ,with your considered experience . Reading your thoughts , makes me think of Djokovic Novak unable to play with the world's best in his field due to bizarre politics. How overwhelmingly sad it must be for you not to be able to actively debate those so called experts in public health in order to have had the best "there could have been" for the pandemic . I believe those plain spoken truckers are having a butterfly effect -maybe a nudge for more to pull back some curtains and question what is really going on .

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morrison the nazi is the worst among them all .... terrible people.

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"DOUG FORD ADMITS VACCINE PASSPORTS DON’T WORK, ‘EVERYONE IS DONE WITH THIS.’"

Just listen to Doug Ford (2 minutes), Prime Minister of Ontario (Canada).

https://forbiddenknowledgetv.net/doug-ford-admits-vaccine-passports-dont-work-everyone-is-done-with-this/

This is a dual citizen of Globalistan and Canada who has crushed resistance in his Province for 2 years.

He now admits on live TV that getting 1 shot or 10 shots won't help in this pandemic.

Something else must be going on in Globalistan that we're not aware of yet.

Anyway, don't count on Ontario to mandate "Vaccines" or "vaccine Passport" from now on. It's over in Ontario.

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"Israel: Ministry of Health, it’s time to admit failure" already admitted defeat in January:

https://www.europereloaded.com/israels-prof-ehud-qimron-ministry-of-health-its-time-to-admit-failure/

Expect an avalanche of white flags from the Covidian cultists.

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"Something else must be going on in Globalistan that we're not aware of yet."

Do you remember Boris Johnson declaring the pandemic over in the UK?

It turned out that he's wanted by the ICC along with many members of his government.

There are many lawsuits in the work for malfeasance around the globe and when I see somebody like Ford who has claimed that vaccines are "Safe and Effective" say overnight that they're useless I can only wait for a couple of weeks to see what's going on behind the scenes.

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I, too, am frustrated that we KNOW that much is going on behind the scenes, which affects our lives to a great degree, and yet we are kept in the dark about it. Above our pay grades.

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I always feel a little smarter after reading one of Geert's presentations, even if I have to read it a few times to "get" even a part of it, and even if his assertions turn out to be incorrect.

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Which assertions where incorrect so far? With the rest I agree.

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Great article. It is obvious to all, at this point, that just about everyone will get Covid and the real issue is REinfections.

On this front, things look bleak, especially for the vaccinated. I read /r/COVID19Positive subreddit and there is an alarming quantity of vaccinated people being reinfected literally every month.

Vaccinated people do not acquire any immunity due to their immune system being trained for Wuhan spikes, and upon challenge with a infection, produce more useless spike proteins. I wrote it a number of times too.

https://igorchudov.substack.com/p/uk-and-the-boosted-monkey-experiment

Thus, as soon as their interferons are depleted, they get reinfected again. I have a whole bunch of highlighted saved messages that I posted on twitter as @ichudov.

Some actually cannot clear the virus at all and just have low grade continual disease. It is not even "long Covid", it is just continuous Covid.

Since Covid spike (in the virus AND Covid Vax) does have some HIV motifs and depletes T cells, repeated infections (and injections) are like a battering ram against the basics of immune systems, so I am not optimistic about the future of these people.

You can think about these individuals as being colonized by Covid and being festering carriers of the virus.

Also be aware that Wuhan Covid as well as Omicron Ba.1 are lab products, very possibly results of developing a vaccine for/or a bioweapon, and do NOT act like a normal virus would.

Examples:

https://twitter.com/ichudov/status/1494362167730180100

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Constant spike protein production by constant boosters and excited immune system creates constant inflammation all over the body. That is NOT good.

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Fantastic and truly invaluable analysis, thank you so much Geert.

I too hope it is not so.

However, when you state: "I am afraid to predict that it will take a disaster before these hardened sinners become fully aware of all the harm they’ve been causing to our very own species." you don't appear to be considering the possibility that "these hardened sinners" as you call them were always fully aware, that in fact it was possibly always a goal.

I hope that too is not so, but evidence increasingly suggests it is.

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Right-Bill Gates would be very happy with rapid depopulation and infertility. I wonder which of the elites qualified for the celebrity (saline) jab?

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From the VAIDS data out of the UK, Israel, Germany and Canada I can say for sure that Bill Gates is very proud now. Instead of just removing 10-15% of the population using "vaccines", he'll get more than 25% for sure before 2025.

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Or, you could just boost your innate immune system by going old school.

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7668174/

"During the sauna the body temperature is elevated to 102° F within 15 to 20 min. This causes dilation of blood vessels in the skin; it produced a loss of about 1 lb of weight due to sweating; it increased heart rate; and it reduced peripheral resistance [45], [46]. The hematological effects of sauna are increases in hemoglobin, white blood cell count, and platelets within normal limits [47]. Sauna also decrease the level of Serum C-reactive protein (CRP) [48], a marker of systemic inflammation. High levels of CRP, i.e., high levels of inflammation, could have an adverse effect on immunity [49]; while lower levels of CRP are associated with less systemic inflammation. There is evidence to show that sauna reduce the incidence of the common cold [50]. White blood cells were increased in a small study (n = 9) after a single session of Finnish sauna; the response was greater in athletes and included increases in neutrophils and monocytes [51]. A cohort study of Finnish sauna users demonstrated a decrease in systemic inflammation and oxidative stress [52].

Another advantage of heat treatments is that hyperthermia treatments result in high levels of IL-6 without activating IL-1-beta or tumor necrosis factor (TNF) [53] potentially preventing cytokine storms (dysregulated immune response) because an increase of IL-6 by itself seems to decrease inflammation [54]. The isolated increase of IL-6 is the way exercise decreases inflammation [55], which is the same way for fasting [56] and for plant-rich diets [57]. The effect of hyperthermia on the coronavirus infection by way of the interferon function seems to be optimal at higher temperatures, 104.9° F [58]. Hyperthermia induces the synthesis of gamma interferon in cell cultures [59]. In rhesus monkeys hyperthermia increased alpha interferon and non-interferon antiviral factors [60]. All this possibly counteracts the effects of the virus since interferon has the ability to slow or stop viral infections."

In the pre-antibiotic era, they would treat Syphilis by giving the patient Malaria to induce high fever and then treat the Malaria with quinine. It's pretty interesting and Dr. Seheult went over this early in his Medcram series. https://youtu.be/H1LHgyfPPQ8?t=171

Human monocyte stimulation by experimental whole body hyperthermia

https://pubmed.ncbi.nlm.nih.gov/12060966/

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Very insightful. I love this natural remedy without synthetic concortion that can induce worst conditions than the disease.

UV light and humidity have also been shown to affect the course of Covid-19. That explains why most west African countries have less prevalence of the disease.

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Dr. Vanden Bossche, can you please comment on this paper,

https://www.medrxiv.org/content/10.1101/2021.05.03.21256520v1.full.pdf

which seems to show that BNT162b2 prevents severe C19 disease by inducing tolerance in the innate immune system to the spike protein? If that's the case, won't vaccinees be left in the face of infection (and repeated re-infection) by Omicron and future escape variants with:

1) a suppressed innate immune response

2) non-neutralizing spike ABs due to OAS

3) only a T-cell response to rely on to clear infection

4) T-cell exhaustion or depletion after repeated re-infection

Also, I was not able to follow the reasoning of the following statement in the current article:

"However, the high incidence of disease across a wide variety of vaccinated age groups is likely to drive a massive surge in the population’s anti-Omicron Ab titers. A large peak of anti-(Omicron) S [anti(O)S] seroprevalence could cause high population-level immune pressure on viral infectiousness. "

Are you saying that, despite OAS, vaccinees will produce new, Omicron-specific Abs?

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Good questions for Dr. Bossche. He does not reply to the comments but sometimes address the questions in further articles.

But your questions are challenging and deserves to be answered.

You pointed out to an important question regarding immune tolerance induced by mRNA vaccines against C19. This is more relevant question than Abs titer, neutralizing capacity, half-life and potent and durability of vaccine induced T and B cells. Vaccinal Abs, B and T cells are irrelevant in my view, because in upper respiratory tract vaccinal Abs (IgA, IgG), T cells are not functional and short-lived in comparison to potency of secretory IgA. And taking into account accessory proteins ORF3b, ORF6, ORF7a, ORF9b and structural protein NSP1 that antagonize type I interferon induction; ORF9c that inhibits cytokine secretion; ORF8 that downregulates MHC-Ι molecules; glycans that mask “nonself” viral peptides with “self-glycans” to avoid antibody detection, all this suggests that any single-protein directed neutralization strategy is rather useless.

Since current C-19 vaccines were developed for prevention of serious disease and death (and not against infection and transmission), I would argue they serve the purpose well (while they have certain downsides). And the prevention of serious disease is achieved by means of immune tolerance, and not neutralizing capacity. The immune tolerance is achieved by training mast cells to release IL-10 and TGF-β, instead of IL-6 and histamine. And secondly mRNA vaccines train mast cells to better interact with regulatory T cells, which also suppress effector T-cell responses, suppress proinflammatory cytokine induction, and desensitize mast cells against FcεRI-mediated degranulation. This immune tolerance results in avoidance of hypersensitivity phase of C19, which, if not prevented, may lead to lethal cascades of hyperinflammation and hypercoagulation.

In reply to your questions answers are as follows:

1) you should distinguish between immune response suppression and immune cell suppression. You can have an effective immune response in form of suppressions of proinflammatory cytokine induction, which is required in severe C19;

2) you should take into account that viral RBD has not changed too much and vaccinal Abs may potentially neutralize the S. But the variants use their accessory and non-structural proteins to suppress and downregulate immune response and avoid detection by means of multiple glycan shields

3) NK cells and phagocytosis play more important part in SC2 initial clearance

4) T-cell exhaustion or depletion is not a such problem because of vaccination. SC2 protein ORF3a effectuates T cell lymphopenia. SC2 glycans also suppress dendritic cells and, therefore, downregulates the only pathway for naïve T cell activation.

With regard to your question about OAS and Omicron-specific Abs even in vaccinees with non-neutralizing but reactive Abs due to OAS there shall be innate polyfunctional Abs with low-affinity against omicron. But in the relevant context the main point of the author was about immune pressure and immune escape. Even with omicron-specific, neutralizing Abs massive (population wide) immune pressure shall push the virus to mutate even further to escape the neutralization.

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The rules in vaccinology have been blatantly broken. The evidence is for all to see.

The constitution has a been subverted and defiled.

The people have not been broken . We keep calm and carry on.

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You mentioned that unvaccinated people who have had the SarsCoV2 and recovered will not be at increased risk of future more virulent strains. What about those of us who are unvaccinated but haven't had a previous infection?

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I’m hard to kill.

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LOL! I may be, too!

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