Syncytia are multinuclear cells that can form either through normal biological processes, such as the mammalian placenta, or under the influence of certain pathogens, such as HIV, via fusion of the plasma membrane.
The continuous evolution of SARS-CoV-2 drives the escape from humoral immunity induced by the Pfizer/Moderna ModRNA vaccines, despite updates and boosters
The continuous evolution of SARS-CoV-2 drives the escape from humoral immunity
induced by the Pfizer/Moderna ModRNA vaccines, despite updates and boosters.
Ronald Palacios Castrillo, M.D., PhD.
Since the onset of the COVID-19 pandemic four years ago, viral sequencing has
continued to document numerous individual mutations in the viral spike protein across
many variants. To assess the ability of humoral immunity mediated by ModRNA
vaccines9pfizer/moderna) to counteract the continuous evolution of SARS-CoV-2,
Roederer et al. [Cell Reports Medicine, DOI: 10.1016/j.xcrm.2024.101850A, published Dec
9, 2024] created a comprehensive panel of pseudoviruses containing each individual
mutation spanning four years of the pandemic. This allowed them to analyze the trade-
offs between adaptation costs and resistance benefits of each mutation.
Their efforts identified numerous mutations that escape humoral immunity induced by
ModRNA vaccines. Across 50 variants and 131 mutants they constructed, they observed
a progressive loss of neutralization across all variants, regardless of the number of
ModRNA booster doses administered. Additionally, they noted increased infectivity and
ACE2 binding.
Notably, the most recent XBB.1.5 booster dose significantly increases titers against most
variants but not against JN.1, KP.2, or KP.3. These findings demonstrate that variants
continue to evade updated ModRNA vaccines, emphasizing the need for alternative
approaches to control SARS-CoV-2 transmission.
It is time to cease administering these Pfizer/Moderna ModRNA injections to children
and adults in order to reduce (if still possible) the growing number of people worldwide
suffering from adverse effects—some severe and even fatal—linked to these injections.
Perhaps we should stop having silly notions of controling transmission and just let it get on with being the fifth common cold. As soon as everyone starts learning about vitamin D and T cells. The sooner we can move on from this virology silliness and do a new chapter. Aliens, or whatever.
This virology silliness killed so far 7 million people. Important to learn from it; so we avoid the same mistakes next time. I am not so worry about the natural virus, but from those created in the labs with gain of function to increase efficiency of infective and infection in humans. Got the news about the H5N1 influenza mutant created at Scripps in Ca and published the detailed recipe to the public So terrorist groups and other kind of criminals can create its own mutant. Influenza has 30-50% mortality( not the highly improved mutant). Important to know this, you bet yes.
It seems clear to me, that as long as 99.99% of the planet continues as it has to complelty ignore the far more important role of T cell immunology, the ball the experts wilk continie to get alkvthe fritcal factors wrong, and they all mostly have been doing all along.
And if they all also continue to never learn anything about the S2 fusion membrane protein, it's homologous nature to hcovs, and it's highly conserved mechanical in nature properties, aka if you mutate it, you break it.
Then they will all continue also to not understand the fundamental core aspects explaining All the COVID immunology.
Also, if famous experts continue to always give their endless presentations without scientific debate and confirmation of factors, all famous experts will keep being able to endlessly guess and speculate on endless theories that all mostly turn out to be wrong.
Especially if the planet keeps refusing to learn T cells.
For example. All videos done by Dr Ben MacFarland for years have all been largely unaware he'd, and nobody ever comments. Brianne barker T cells series also had 20+ videos with nobody being able to comment.
All the short learning T cell videos on YouTube, have all also received less than 40,000 views in the entire four years, showing that even docotrs aren't bothering to learn basics, let alone and army of conspiracy theorists claiming to do research.
And worst of all. 99.99% of the planet, STILL think Donald trump said "inject bleach".
T cells with no memory, cytotoxic T cells, are not fast enough to stop completely the replication and spreading of the virus, so they are not a perfect tool, as they react not immediately, after the virus has infected the cell. Well trained NK cells , with epigenetically acquired memory, are faster, they prevent replication, so they sterilize the viral infection. This is what Geert is telling us.
People with their 3rd or more jab and (consequent) Covid disease seem to get more exhausted (physically and mentally) each time. So their CTLs are working but there is a cost. Also, the repeated injections and re-infections are prompting the various spike pathologies including weakened immune systems, micro-clotting, and cancer vulnerability. Since this is an incremental and low-probability but high-numbers process, perhaps the result will be like the internal rotting of old trees that seem solid until a threshold is reached and then they collapse completely. I wonder if Geert's predictions envision this kind of scenario.
The injections are not giving "spike pathologies". They are giving cytotoxic T cells attack and destruction pathologies. (Bhakdi, Campbell, GIRARDOT, Weinstein ) followed by T cells exhaustion and lymphocytophenia (Dalgleish) .
"Besides serving as the crucial factor mediating virus entry, CoV-2-S also harms the host cells and organs in many ways. A. CoV-2-S glues neighboring cells together to form a giant cell containing multiple nuclei (Syncytium). B. CoV-2-S binds to cell surface-localized innate immune receptors to inflame tissue cells and peripheral immune cells. C. CoV-2-S damages the vascular endothelial cells and activates the complement system, leading to the formation of microthrombi in small vessels. D. CoV-2-S cross links antigen presenting cells and T cells, activating a large T cell population (2%–20%) by skipping the antigen selection process." https://doi.org/10.1016/j.smhs.2023.03.004
"SARS-CoV-2 spike protein induces loss of the BBB integrity" "SARS-CoV-2 subunit S1 triggers increased BBB permeability in a 3D tissue engineered model of the BBB" https://doi.org/10.1016/j.nbd.2020.105131
"S1 might impair mitochondrial function in human cardiomyocytes by altering Δψm, mCa2+ overload, ROS accumulation, and mitochondrial dynamics via ACE2" https://doi.org/10.3390/cells12060877
GEET shouldn't be talking about "T cells wth no memory", since they are literally called "memory T cells".
And if he does want to talk about it. He should discuss it with us "T cell guys" first, not just dismiss an entire department of immunology out of hand. And he certainly shouldn't just do presentations and not talk each point over with another intelligent immunologist.
According to Geert, there should have been 2 billion dead over the last 4 months. And there aren't.
And as you know,vwe live on a planet where it turns out almost all doctors get EVERYTNIG wrong about immunogky, time after time.
Has professor Calhills 5 billion dead from antigen dependent enhancement, happened yet? No.
When is the Tsunami of Death, and what percentage of injected people will die in order to constitute a tsunami? Will it be enough to make the facts undeniable, or can it be gaslit and swept under the rug as is so far the case?
Geert, on what date do you say you were wrong and there will be no Tsunami? December 2024 or later? Or given your strong belief in this you can never say that? I've directed many people to your work but disappointed that you haven't stated your new time line esp as you gave the last predication with such certainty
"Cov2-S glues cells together (syncita)". = Glues together . Not destroy.
"Covs2 spike binds to cell surface- localised innate to inflamme tissues cells " inflammation is NOT destruction.
"Covs2-S damages the endothelium " . That is just an erroneous statement without an explanation.
"Activates the complement system".
Actually , spike bound with antibodies activated the complement system. And it is the complete system...Phagocytes, which then destroys cells. The presence of spike triggers the Phagocytes to attack. But the spike doesn't do it. Same as "guns don't kill people, bullets do".
"Spike induces loss of integrity of the blood brain barrier". No. Wrong. Spike expressed on the surface induces cytotoxic T cells, to destroy the blood brain barrier.
It's not the spike destroying cells.
It's the immune response, that destroys the cells.
If it was a different foreign protein. The same immune response would destroy the cells.
I'm so sick of explaining this to a planet of morons, including experts.
Yes. All the scientists and baffled. You know that. Also, every other human is baffled. I'm the only person who isn't baffled. Literally.
If people don't know what the Darkforce is. Then your in the dark. Everyone is effected by the Darkforce, and don't realise it.
As Bret WEINSTEIN said.
"I am done with sense making, but there is some need to grapple with the evidence. We have , some FORCE that is keeping us in the dark. It is denying us access to readily available answers, and so we keep injuring ourselves. ".
Yes, you are correct. Syncytia formation allows for direct cell-to-cell transmission of the virus, thereby bypassing extracellular spaces where antibodies operate. However, this process does not necessarily evade cytotoxic T lymphocyte (CTL) detection, as CTLs rely on intracellular antigen presentation via MHC class I (MHCI) molecules. Here's a more detailed breakdown of the immunological implications of syncytia formation:
---
1. Syncytia Formation and Antibody Evasion
How it works: Syncytia form when infected cells fuse with neighboring uninfected cells, creating multinucleated cells. This process allows the virus to move directly from one cell to another without being exposed to the extracellular space.
Antibody evasion: Since antibodies operate in extracellular fluids (plasma, interstitial fluid), they can neutralize free viral particles but cannot directly affect viruses inside cells. Syncytia formation effectively "hides" the virus from antibody-mediated neutralization.
Implication for immune evasion: This mechanism is a well-known strategy used by other viruses, like HIV, measles, and herpesviruses, to evade antibody responses. For SARS-CoV-2, syncytia formation is observed more prominently in severe cases and with certain variants (e.g., Delta) due to changes in the spike protein that enhance fusogenic activity.
---
2. Syncytia Formation and Cytotoxic T Lymphocytes (CTLs)
How CTLs work: Cytotoxic T cells recognize viral peptides presented on MHCI molecules at the surface of infected cells. Once the CTL recognizes a foreign antigen (derived from viral proteins), it triggers apoptosis (cell death) in the infected cell.
Does syncytia formation evade CTL responses?
No, it does not directly prevent CTL detection. MHCI molecules are still present on the surface of syncytia, and viral peptides (derived from the virus replicating inside the cell) will still be presented.
Yes, indirectly, in that syncytia are larger and more complex than individual infected cells. A large, multinucleated syncytium may present viral antigens from multiple viral genomes simultaneously, which could confuse or "dilute" the CTL response. However, this is not a complete form of immune escape.
Since CTLs are designed to detect intracellular infections, they remain capable of recognizing and destroying cells that are part of a syncytium. As a result, CTL responses are more robust against this form of viral evasion than antibody responses.
---
3. Practical Implications for Immune Evasion
Antibody-centric immunity: If immunity is heavily reliant on neutralizing antibodies (e.g., from vaccines or monoclonal antibody therapy), syncytia formation can allow the virus to evade detection and promote persistent infection.
T-cell-centric immunity: Since CTLs do not rely on extracellular detection, they remain effective against syncytia. This is why T-cell-mediated immunity is crucial for controlling viral infections that use syncytia as an evasion strategy. Memory T cells can recognize and respond to diverse viral peptides, even if they are from new variants.
SARS-CoV-2-specific implications: Vaccination and natural infection generate both antibody and T-cell responses. If syncytia formation increases due to the evolution of more fusogenic spike protein variants, CTLs (rather than antibodies) may play a more critical role in clearing infections. This could explain why T-cell immunity (which remains effective across variants) is essential for long-term protection against severe disease, even when antibody-mediated immunity is less effective against new variants.
---
Summary
Syncytia formation allows for direct cell-to-cell spread of the virus, bypassing extracellular spaces where antibodies act, thus evading neutralization by antibodies.
Cytotoxic T lymphocytes (CTLs) are not evaded by syncytia formation because viral antigens are still presented on MHC class I molecules. CTLs can recognize and kill syncytia-forming cells just as they would any other infected cell.
Syncytia formation represents a classic immune evasion tactic used by several viruses, but it poses a greater challenge to antibody-based immunity than to T-cell-mediated immunity.
In essence, CTL-mediated immunity remains a critical defense against syncytia-forming viruses like SARS-CoV-2, especially as new, more fusogenic variants arise.
According to Geert, CTLs with no memory (no antigen presentation via MHC class I (MHCI) molecules), are the ones in play amongst vaccinated people to try to stop viral infections. But these are not sterilizing CTLs.
Yes, it is plausible that pre-existing memory T cells from past exposure to common cold coronaviruses played a role in keeping many people asymptomatic or experiencing mild symptoms during SARS-CoV-2 infection. This concept is supported by several studies on cross-reactive T cell immunity. Here’s a breakdown of how and why this happens:
1. Pre-Existing T Cell Immunity
Cross-Reactivity: Common cold coronaviruses (like OC43, 229E, NL63, and HKU1) share structural similarities with SARS-CoV-2, particularly in the S (spike) protein and other conserved proteins (like nucleocapsid (N) and membrane (M) proteins). This means that T cells primed by these seasonal coronaviruses may recognize similar parts (epitopes) of SARS-CoV-2.
Cross-Reactive Memory T Cells: When a person is infected with SARS-CoV-2, memory T cells previously primed by common cold coronaviruses may recognize these conserved epitopes. Upon recognition, these T cells mount a rapid immune response, potentially preventing viral replication before it can cause symptoms.
---
2. Mechanism of Protection
CD4+ Helper T Cells: These T cells support B cells in producing antibodies and activate other immune cells. If cross-reactive CD4+ T cells recognize SARS-CoV-2 epitopes, they can accelerate the immune response, even without prior exposure to SARS-CoV-2.
CD8+ Cytotoxic T Cells: These T cells directly kill infected cells. If cross-reactive memory CD8+ T cells recognize SARS-CoV-2 epitopes, they can quickly destroy infected cells, limiting viral replication before symptoms appear.
Early Control of the Virus: Since T cells work earlier in the immune response than antibodies, they can prevent symptoms from occurring. If the infection is controlled quickly, the person may remain asymptomatic.
---
3. Evidence Supporting This Idea
Presence of Cross-Reactive T Cells in Unexposed Individuals: Studies have shown that 40-60% of unexposed individuals have T cells that recognize SARS-CoV-2. This was surprising early in the pandemic but was later explained by exposure to common cold coronaviruses.
Asymptomatic Infections: Populations with high exposure to common coronaviruses (like children) have had higher rates of asymptomatic infection. It’s believed that their immune systems, already "trained" by previous infections, are more effective at controlling SARS-CoV-2.
T Cells More Important Than Antibodies: Antibodies decline over time, but T cells remain for much longer, often lasting for years or even decades. As a result, many researchers argue that T cells, not antibodies, play the dominant role in protection against reinfection.
---
4. Key Studies
Le Bert et al. (2020, Nature): Found SARS-CoV-2-reactive T cells in people who had never been exposed to SARS-CoV-2, suggesting that these T cells were primed by common cold coronaviruses.
Mateus et al. (2020, Science): Showed that 40-60% of unexposed individuals had T cells that recognized SARS-CoV-2, indicating the existence of cross-reactive T cells.
Ng et al. (2020, Nature Immunology): Demonstrated that T cells from previous coronaviruses were able to recognize and respond to SARS-CoV-2 epitopes, potentially explaining the large number of asymptomatic infections.
---
5. Why Some People Get Sick While Others Stay Asymptomatic
Strength of Cross-Reactive T Cell Memory: Some people may have stronger T cell memory from prior coronavirus exposure, while others may not.
Age and Exposure History: Children, who are frequently exposed to common cold coronaviruses, may have more recent and robust cross-reactive T cell memory, which could explain why they often experience mild or asymptomatic COVID-19.
Other Factors: Genetics (like differences in HLA/MHC molecules) and immune system variability also play a role.
---
Conclusion
Yes, it is reasonable to say that pre-existing cross-reactive memory T cells from past exposure to common cold coronaviruses likely helped many people remain asymptomatic when exposed to SARS-CoV-2. These memory T cells recognize shared viral epitopes and trigger a faster immune response, controlling the infection before symptoms can develop. This idea is supported by multiple studies showing that many unexposed people had SARS-CoV-2-reactive T cells, likely due to prior exposure to seasonal coronaviruses.
According to Geert, there is no memory for (common to several pathogens) self-like "universal" epitopes (this would be harmful due to autoimmunity issues), this is why CTLs react after viral replication.
Activation of interferons . after flu, cold and other infections, could be the cause of the group immunity that is refraining covid from causing greater havoc these past two winters.
Both OC43 (a seasonal human coronavirus) and SARS-CoV-2 (the virus responsible for COVID-19) are beta-coronaviruses, and they share some degree of sequence and structural similarity. This similarity can lead to cross-reactive T cell responses. Here’s a summary of the key universal shared homologous epitopes recognized by T cells on these two viruses:
---
1. Types of Shared Epitopes
Spike (S) Protein Epitopes:
The S protein is the most immunogenic viral protein. Certain conserved regions, especially in the S2 subunit (which facilitates membrane fusion), are more conserved across coronaviruses.
Example: Regions around heptad repeats (HR1, HR2) are relatively conserved in OC43 and SARS-CoV-2.
Nucleocapsid (N) Protein Epitopes:
The N protein is more conserved across coronaviruses than the S protein. T cells often recognize epitopes from the N protein due to its intracellular abundance and its role in viral RNA packaging.
Example: T cell responses have been identified against conserved N-terminal and C-terminal epitopes.
Membrane (M) and Envelope (E) Proteins:
Although the M and E proteins are smaller and less immunogenic, certain regions are highly conserved. They may serve as shared epitopes, but they are less well characterized compared to the S and N proteins.
---
2. CD4+ and CD8+ T Cell Epitopes
CD4+ T cell Epitopes (presented on MHC class II)
Found in regions of S, N, and M proteins that are conserved across coronaviruses.
CD4+ T cells recognize peptides derived from extracellular or endosomal viral proteins.
CD8+ T cell Epitopes (presented on MHC class I)
Primarily derived from intracellular proteins like N protein and portions of the S protein.
Cross-reactive CD8+ T cell responses are frequently found in memory T cells of individuals with previous OC43 exposure, even if they never had COVID-19.
---
3. Examples of Specific Shared Epitopes
S Protein Epitope (S816-S830):
Shared between SARS-CoV-2 and seasonal betacoronaviruses like OC43. T cells recognize it due to its role in membrane fusion.
N Protein Epitope (N105-N120):
A highly conserved T cell epitope found in both OC43 and SARS-CoV-2, capable of inducing strong CD8+ T cell responses.
M Protein Epitope (M50-M65):
While less studied, regions within the membrane protein show strong conservation and are predicted to be cross-reactive epitopes.
---
4. How are These Epitopes Recognized?
Cross-reactive T Cell Immunity:
T cells specific to epitopes in OC43 can recognize the homologous epitopes in SARS-CoV-2. This may explain the presence of pre-existing immunity in people never exposed to SARS-CoV-2.
Memory T cells from prior infections with common cold coronaviruses like OC43 can be "recalled" upon infection with SARS-CoV-2.
Immunodominance:
Not all shared epitopes elicit strong immune responses. Some may be more "immunodominant" due to their better presentation on MHC molecules or higher availability.
---
5. Implications for Immunity and Vaccination
Cross-reactive immunity may reduce disease severity of COVID-19 in people previously exposed to OC43 or other seasonal coronaviruses.
Understanding shared T cell epitopes could lead to the development of a pan-coronavirus vaccine targeting these conserved regions.
---
If you'd like, I can provide a more detailed list of specific peptide sequences or references to studies identifying these epitopes.
The memory T cells have been keeping most people safe this entire time. Just cos an entire planet of experts and doctors just "forgot" basic pre existing cross reactive T cell immunity, and the second half of the spike, doesn't mean they aren't and haven't been doing a great job this entire time .
Jews deceived all nations and caused so many sufferings, killings and blood rituals against children since the old times, read their Chronicles! Jews even disobeyed God and he punished them by sending them wandering for 40 years, then so peace for 40 years which makes 80 years then they will disappear. This is very clear in their TORAH and not their fake heinous Talmud, also it is in the Quran! Another point I disagree with is Hitler just like Mandela was classed a s terrorists yet he was freedom fighter for all Africans. I am African but not South African. Hitler stopped Jews pedophilia, theft, usury and monopolizing the bank and especially stopped the loans with extortionate interests which burdened the nation and the poor in Germany, that's what IMF is doing now. He closed ALL clubs and bars where gays and pedophiles were fornicating their sordid evil. Unfortunately, the West is controlled and brainwashed by the Zionist propaganda for decades.
Decades ago, Gustave Le Bon said: "The more educated people are, the more vulnerable they are for Mass Formation" and that's exactly what we saw in the West (Secular) who believe and worship (not God) but their governments which are made of these Elite Globalist and WEF Young Leaders. For years, I have been telling my Western friends that the Western government are looting us in Africa, they put puppets in charge of us who are paid tons of money to implement the West's EVIL agenda hence we never believed in our governments like the Westerners do. Told them about what Bill Gates of Hell was doing to African especially in the villages when his Evil Foundation were using us as guinea pigs since early 70's. Gates sterilized millions of women with Tetanus vaccines laced with HCG, then he injected many with HIV who almost all developed AIDS after 2 to 5 years and died because Bill Gated of HELL who gave many Africans the vaccines, wasn't going to give the cure for free, in fact, the price was so high, no one could afford it, therefore many died of AIDS. No to forget he jabbed Africans with Ebola and thousands died then he experimented with Korona vaccines and some children died but anyway, they still went ahead with it vaccinated the whole West who did not fear God or putting something into their bodied that was so quickly available from Big pharma that had so many lawsuits and payments like Pfizer. I could not believe what I was hearing and seen. At least in Africa, we might live under dictators put on us by the West but we do question everything and do refuse things without been punished or losing our jobs. We didn't have severe lockdowns either hence now we do not have Sudden Death, Long Covid or Myocarditis as you have in the West except for South Africa who injected so many of its citizens. The REAL enemy like Julian Assange said: "Forget Russia, forget China, the real enemy is Israel".
Both China and Russia have been in Africa just like USA, France, Germany, Netherlands etc but they have so far never killed anyone, never injected anyone, never invaded anyone and never looted in any African country, like the so called Western Civilized democracies! Russia and China have built bridges, roads, school, hospitals, dams and more. People in the West need to wake up and rise up against their own governments who are killing them, lying o them, taking to wars and implementing total control and depopulation under the gaze of WEF and WHO which still pushing for the WHO Pandemic Amendment and which 47 African countries rejected and saved the West and the World. However, this isn't the end of WHO Amendments as most of the WEST has signed up for it and other countries, they are cooking something soon in 2025! God help those who resist and do not consent. Truth Always Prevails and Evil can never Win!
Africa “winning” I find to be relative in this situation. I feel like those regions are in just as bad if not worse situations if the immune escape pans out. Mass death in other countries would significantly bring down trade and technological communication and other networks, and I’m one to assume the continent will descend into anarchy and famine to a point that a lot would die there also even if they aren’t as affected.
Thanks for sharing this Dr Bossche much appreciated 🙏
Wiki, this HIV thing pops up again:
Syncytia:
---------
Syncytia are multinuclear cells that can form either through normal biological processes, such as the mammalian placenta, or under the influence of certain pathogens, such as HIV, via fusion of the plasma membrane.
Maybe someone should add more examples of pathogens to that Wikipedia entry: Respiratory Syncytial Virus (RSV), and SARS-CoV-2 variants (https://pmc.ncbi.nlm.nih.gov/articles/PMC8646911/).
Please read this
The continuous evolution of SARS-CoV-2 drives the escape from humoral immunity induced by the Pfizer/Moderna ModRNA vaccines, despite updates and boosters
The continuous evolution of SARS-CoV-2 drives the escape from humoral immunity
induced by the Pfizer/Moderna ModRNA vaccines, despite updates and boosters.
Ronald Palacios Castrillo, M.D., PhD.
Since the onset of the COVID-19 pandemic four years ago, viral sequencing has
continued to document numerous individual mutations in the viral spike protein across
many variants. To assess the ability of humoral immunity mediated by ModRNA
vaccines9pfizer/moderna) to counteract the continuous evolution of SARS-CoV-2,
Roederer et al. [Cell Reports Medicine, DOI: 10.1016/j.xcrm.2024.101850A, published Dec
9, 2024] created a comprehensive panel of pseudoviruses containing each individual
mutation spanning four years of the pandemic. This allowed them to analyze the trade-
offs between adaptation costs and resistance benefits of each mutation.
Their efforts identified numerous mutations that escape humoral immunity induced by
ModRNA vaccines. Across 50 variants and 131 mutants they constructed, they observed
a progressive loss of neutralization across all variants, regardless of the number of
ModRNA booster doses administered. Additionally, they noted increased infectivity and
ACE2 binding.
Notably, the most recent XBB.1.5 booster dose significantly increases titers against most
variants but not against JN.1, KP.2, or KP.3. These findings demonstrate that variants
continue to evade updated ModRNA vaccines, emphasizing the need for alternative
approaches to control SARS-CoV-2 transmission.
It is time to cease administering these Pfizer/Moderna ModRNA injections to children
and adults in order to reduce (if still possible) the growing number of people worldwide
suffering from adverse effects—some severe and even fatal—linked to these injections.
Perhaps we should stop having silly notions of controling transmission and just let it get on with being the fifth common cold. As soon as everyone starts learning about vitamin D and T cells. The sooner we can move on from this virology silliness and do a new chapter. Aliens, or whatever.
T cells are excellent. Vit D ok but overrated
This virology silliness killed so far 7 million people. Important to learn from it; so we avoid the same mistakes next time. I am not so worry about the natural virus, but from those created in the labs with gain of function to increase efficiency of infective and infection in humans. Got the news about the H5N1 influenza mutant created at Scripps in Ca and published the detailed recipe to the public So terrorist groups and other kind of criminals can create its own mutant. Influenza has 30-50% mortality( not the highly improved mutant). Important to know this, you bet yes.
I recommend this Hotez video to all.
https://petermcculloughmd.substack.com/p/unhinged-hotez-bio-pharmaceutical?publication_id=1119676&utm_campaign=email-post-title&r=1lccvj&utm_medium=email
It seems clear to me, that as long as 99.99% of the planet continues as it has to complelty ignore the far more important role of T cell immunology, the ball the experts wilk continie to get alkvthe fritcal factors wrong, and they all mostly have been doing all along.
And if they all also continue to never learn anything about the S2 fusion membrane protein, it's homologous nature to hcovs, and it's highly conserved mechanical in nature properties, aka if you mutate it, you break it.
Then they will all continue also to not understand the fundamental core aspects explaining All the COVID immunology.
Also, if famous experts continue to always give their endless presentations without scientific debate and confirmation of factors, all famous experts will keep being able to endlessly guess and speculate on endless theories that all mostly turn out to be wrong.
Especially if the planet keeps refusing to learn T cells.
For example. All videos done by Dr Ben MacFarland for years have all been largely unaware he'd, and nobody ever comments. Brianne barker T cells series also had 20+ videos with nobody being able to comment.
All the short learning T cell videos on YouTube, have all also received less than 40,000 views in the entire four years, showing that even docotrs aren't bothering to learn basics, let alone and army of conspiracy theorists claiming to do research.
And worst of all. 99.99% of the planet, STILL think Donald trump said "inject bleach".
When he didn't.
T cells with no memory, cytotoxic T cells, are not fast enough to stop completely the replication and spreading of the virus, so they are not a perfect tool, as they react not immediately, after the virus has infected the cell. Well trained NK cells , with epigenetically acquired memory, are faster, they prevent replication, so they sterilize the viral infection. This is what Geert is telling us.
And it doesn't help that geet constantly decides to change up the commonly known scientific terms for everything.
"T cells with no memory" are actually called "naive" T cells.
Your comment mentioned naive T cells. And NK cells.
And complelty ignored T cells WITH memory.
Called "memory T cells".
Killer T cells.
Cytotoxic T killer lymphocytes.
The thing that has been destroying everyone's organs after the jab. The T cells attack.
Like Dr bhakdi told you all for 3 years but you all just ignored him.
People with their 3rd or more jab and (consequent) Covid disease seem to get more exhausted (physically and mentally) each time. So their CTLs are working but there is a cost. Also, the repeated injections and re-infections are prompting the various spike pathologies including weakened immune systems, micro-clotting, and cancer vulnerability. Since this is an incremental and low-probability but high-numbers process, perhaps the result will be like the internal rotting of old trees that seem solid until a threshold is reached and then they collapse completely. I wonder if Geert's predictions envision this kind of scenario.
The injections are not giving "spike pathologies". They are giving cytotoxic T cells attack and destruction pathologies. (Bhakdi, Campbell, GIRARDOT, Weinstein ) followed by T cells exhaustion and lymphocytophenia (Dalgleish) .
No spike has ever destroyed a cell.
Are you sure about that?
"Besides serving as the crucial factor mediating virus entry, CoV-2-S also harms the host cells and organs in many ways. A. CoV-2-S glues neighboring cells together to form a giant cell containing multiple nuclei (Syncytium). B. CoV-2-S binds to cell surface-localized innate immune receptors to inflame tissue cells and peripheral immune cells. C. CoV-2-S damages the vascular endothelial cells and activates the complement system, leading to the formation of microthrombi in small vessels. D. CoV-2-S cross links antigen presenting cells and T cells, activating a large T cell population (2%–20%) by skipping the antigen selection process." https://doi.org/10.1016/j.smhs.2023.03.004
"SARS-CoV-2 spike protein induces loss of the BBB integrity" "SARS-CoV-2 subunit S1 triggers increased BBB permeability in a 3D tissue engineered model of the BBB" https://doi.org/10.1016/j.nbd.2020.105131
"The SARS-CoV-2 (infection or vaccine produced) spike protein can bind to the ACE2 receptor on platelets, leading to their activation [https://doi.org/10.1186/s13045-020-00954-7], and it can cause fibrinogen-resistant blood clots [https://doi.org/10.1042/BSR20210611]. Spike protein fragments can also be amyloidogenic on their own [https://doi.org/10.1021/jacs.2c03925]"
"S1 might impair mitochondrial function in human cardiomyocytes by altering Δψm, mCa2+ overload, ROS accumulation, and mitochondrial dynamics via ACE2" https://doi.org/10.3390/cells12060877
GEET shouldn't be talking about "T cells wth no memory", since they are literally called "memory T cells".
And if he does want to talk about it. He should discuss it with us "T cell guys" first, not just dismiss an entire department of immunology out of hand. And he certainly shouldn't just do presentations and not talk each point over with another intelligent immunologist.
According to Geert, there should have been 2 billion dead over the last 4 months. And there aren't.
And as you know,vwe live on a planet where it turns out almost all doctors get EVERYTNIG wrong about immunogky, time after time.
Has professor Calhills 5 billion dead from antigen dependent enhancement, happened yet? No.
When is the Tsunami of Death, and what percentage of injected people will die in order to constitute a tsunami? Will it be enough to make the facts undeniable, or can it be gaslit and swept under the rug as is so far the case?
Geert, on what date do you say you were wrong and there will be no Tsunami? December 2024 or later? Or given your strong belief in this you can never say that? I've directed many people to your work but disappointed that you haven't stated your new time line esp as you gave the last predication with such certainty
Untill there is herd immunity, mass death is the correct prediction.
Not happening.
Increased death, yes.
Tsunami of death, no.
It's about 4 to 6 months overdue. According to Geert's 200% sure calculations.
Yes. Take the first example.
"Cov2-S glues cells together (syncita)". = Glues together . Not destroy.
"Covs2 spike binds to cell surface- localised innate to inflamme tissues cells " inflammation is NOT destruction.
"Covs2-S damages the endothelium " . That is just an erroneous statement without an explanation.
"Activates the complement system".
Actually , spike bound with antibodies activated the complement system. And it is the complete system...Phagocytes, which then destroys cells. The presence of spike triggers the Phagocytes to attack. But the spike doesn't do it. Same as "guns don't kill people, bullets do".
"Spike induces loss of integrity of the blood brain barrier". No. Wrong. Spike expressed on the surface induces cytotoxic T cells, to destroy the blood brain barrier.
It's not the spike destroying cells.
It's the immune response, that destroys the cells.
If it was a different foreign protein. The same immune response would destroy the cells.
I'm so sick of explaining this to a planet of morons, including experts.
Scientists baffled? hahahahahahahahahahaha
Yes. All the scientists and baffled. You know that. Also, every other human is baffled. I'm the only person who isn't baffled. Literally.
If people don't know what the Darkforce is. Then your in the dark. Everyone is effected by the Darkforce, and don't realise it.
As Bret WEINSTEIN said.
"I am done with sense making, but there is some need to grapple with the evidence. We have , some FORCE that is keeping us in the dark. It is denying us access to readily available answers, and so we keep injuring ourselves. ".
That's exactly what's going on.
Yes, you are correct. Syncytia formation allows for direct cell-to-cell transmission of the virus, thereby bypassing extracellular spaces where antibodies operate. However, this process does not necessarily evade cytotoxic T lymphocyte (CTL) detection, as CTLs rely on intracellular antigen presentation via MHC class I (MHCI) molecules. Here's a more detailed breakdown of the immunological implications of syncytia formation:
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1. Syncytia Formation and Antibody Evasion
How it works: Syncytia form when infected cells fuse with neighboring uninfected cells, creating multinucleated cells. This process allows the virus to move directly from one cell to another without being exposed to the extracellular space.
Antibody evasion: Since antibodies operate in extracellular fluids (plasma, interstitial fluid), they can neutralize free viral particles but cannot directly affect viruses inside cells. Syncytia formation effectively "hides" the virus from antibody-mediated neutralization.
Implication for immune evasion: This mechanism is a well-known strategy used by other viruses, like HIV, measles, and herpesviruses, to evade antibody responses. For SARS-CoV-2, syncytia formation is observed more prominently in severe cases and with certain variants (e.g., Delta) due to changes in the spike protein that enhance fusogenic activity.
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2. Syncytia Formation and Cytotoxic T Lymphocytes (CTLs)
How CTLs work: Cytotoxic T cells recognize viral peptides presented on MHCI molecules at the surface of infected cells. Once the CTL recognizes a foreign antigen (derived from viral proteins), it triggers apoptosis (cell death) in the infected cell.
Does syncytia formation evade CTL responses?
No, it does not directly prevent CTL detection. MHCI molecules are still present on the surface of syncytia, and viral peptides (derived from the virus replicating inside the cell) will still be presented.
Yes, indirectly, in that syncytia are larger and more complex than individual infected cells. A large, multinucleated syncytium may present viral antigens from multiple viral genomes simultaneously, which could confuse or "dilute" the CTL response. However, this is not a complete form of immune escape.
Since CTLs are designed to detect intracellular infections, they remain capable of recognizing and destroying cells that are part of a syncytium. As a result, CTL responses are more robust against this form of viral evasion than antibody responses.
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3. Practical Implications for Immune Evasion
Antibody-centric immunity: If immunity is heavily reliant on neutralizing antibodies (e.g., from vaccines or monoclonal antibody therapy), syncytia formation can allow the virus to evade detection and promote persistent infection.
T-cell-centric immunity: Since CTLs do not rely on extracellular detection, they remain effective against syncytia. This is why T-cell-mediated immunity is crucial for controlling viral infections that use syncytia as an evasion strategy. Memory T cells can recognize and respond to diverse viral peptides, even if they are from new variants.
SARS-CoV-2-specific implications: Vaccination and natural infection generate both antibody and T-cell responses. If syncytia formation increases due to the evolution of more fusogenic spike protein variants, CTLs (rather than antibodies) may play a more critical role in clearing infections. This could explain why T-cell immunity (which remains effective across variants) is essential for long-term protection against severe disease, even when antibody-mediated immunity is less effective against new variants.
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Summary
Syncytia formation allows for direct cell-to-cell spread of the virus, bypassing extracellular spaces where antibodies act, thus evading neutralization by antibodies.
Cytotoxic T lymphocytes (CTLs) are not evaded by syncytia formation because viral antigens are still presented on MHC class I molecules. CTLs can recognize and kill syncytia-forming cells just as they would any other infected cell.
Syncytia formation represents a classic immune evasion tactic used by several viruses, but it poses a greater challenge to antibody-based immunity than to T-cell-mediated immunity.
In essence, CTL-mediated immunity remains a critical defense against syncytia-forming viruses like SARS-CoV-2, especially as new, more fusogenic variants arise.
According to Geert, CTLs with no memory (no antigen presentation via MHC class I (MHCI) molecules), are the ones in play amongst vaccinated people to try to stop viral infections. But these are not sterilizing CTLs.
Yes, it is plausible that pre-existing memory T cells from past exposure to common cold coronaviruses played a role in keeping many people asymptomatic or experiencing mild symptoms during SARS-CoV-2 infection. This concept is supported by several studies on cross-reactive T cell immunity. Here’s a breakdown of how and why this happens:
1. Pre-Existing T Cell Immunity
Cross-Reactivity: Common cold coronaviruses (like OC43, 229E, NL63, and HKU1) share structural similarities with SARS-CoV-2, particularly in the S (spike) protein and other conserved proteins (like nucleocapsid (N) and membrane (M) proteins). This means that T cells primed by these seasonal coronaviruses may recognize similar parts (epitopes) of SARS-CoV-2.
Cross-Reactive Memory T Cells: When a person is infected with SARS-CoV-2, memory T cells previously primed by common cold coronaviruses may recognize these conserved epitopes. Upon recognition, these T cells mount a rapid immune response, potentially preventing viral replication before it can cause symptoms.
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2. Mechanism of Protection
CD4+ Helper T Cells: These T cells support B cells in producing antibodies and activate other immune cells. If cross-reactive CD4+ T cells recognize SARS-CoV-2 epitopes, they can accelerate the immune response, even without prior exposure to SARS-CoV-2.
CD8+ Cytotoxic T Cells: These T cells directly kill infected cells. If cross-reactive memory CD8+ T cells recognize SARS-CoV-2 epitopes, they can quickly destroy infected cells, limiting viral replication before symptoms appear.
Early Control of the Virus: Since T cells work earlier in the immune response than antibodies, they can prevent symptoms from occurring. If the infection is controlled quickly, the person may remain asymptomatic.
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3. Evidence Supporting This Idea
Presence of Cross-Reactive T Cells in Unexposed Individuals: Studies have shown that 40-60% of unexposed individuals have T cells that recognize SARS-CoV-2. This was surprising early in the pandemic but was later explained by exposure to common cold coronaviruses.
Asymptomatic Infections: Populations with high exposure to common coronaviruses (like children) have had higher rates of asymptomatic infection. It’s believed that their immune systems, already "trained" by previous infections, are more effective at controlling SARS-CoV-2.
T Cells More Important Than Antibodies: Antibodies decline over time, but T cells remain for much longer, often lasting for years or even decades. As a result, many researchers argue that T cells, not antibodies, play the dominant role in protection against reinfection.
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4. Key Studies
Le Bert et al. (2020, Nature): Found SARS-CoV-2-reactive T cells in people who had never been exposed to SARS-CoV-2, suggesting that these T cells were primed by common cold coronaviruses.
Mateus et al. (2020, Science): Showed that 40-60% of unexposed individuals had T cells that recognized SARS-CoV-2, indicating the existence of cross-reactive T cells.
Ng et al. (2020, Nature Immunology): Demonstrated that T cells from previous coronaviruses were able to recognize and respond to SARS-CoV-2 epitopes, potentially explaining the large number of asymptomatic infections.
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5. Why Some People Get Sick While Others Stay Asymptomatic
Strength of Cross-Reactive T Cell Memory: Some people may have stronger T cell memory from prior coronavirus exposure, while others may not.
Age and Exposure History: Children, who are frequently exposed to common cold coronaviruses, may have more recent and robust cross-reactive T cell memory, which could explain why they often experience mild or asymptomatic COVID-19.
Other Factors: Genetics (like differences in HLA/MHC molecules) and immune system variability also play a role.
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Conclusion
Yes, it is reasonable to say that pre-existing cross-reactive memory T cells from past exposure to common cold coronaviruses likely helped many people remain asymptomatic when exposed to SARS-CoV-2. These memory T cells recognize shared viral epitopes and trigger a faster immune response, controlling the infection before symptoms can develop. This idea is supported by multiple studies showing that many unexposed people had SARS-CoV-2-reactive T cells, likely due to prior exposure to seasonal coronaviruses.
According to Geert, there is no memory for (common to several pathogens) self-like "universal" epitopes (this would be harmful due to autoimmunity issues), this is why CTLs react after viral replication.
Well you keep listening to geert then.
Note that Geert can't even come to discuss in his own channel.
But you keep listening to geert.
Activation of interferons . after flu, cold and other infections, could be the cause of the group immunity that is refraining covid from causing greater havoc these past two winters.
Acquired immunity, is what has always been preventing COVID from causing havoc.
And a lot of people. learned to get vitamin D. That helped. Especially vulnerable .
No. It isn't.
It's normal immunity stuff everybody should have learned 5 years ago, but still haven't.
But you are all so busy obsessed with what you think individually, you all don't learn anything ever.
Both OC43 (a seasonal human coronavirus) and SARS-CoV-2 (the virus responsible for COVID-19) are beta-coronaviruses, and they share some degree of sequence and structural similarity. This similarity can lead to cross-reactive T cell responses. Here’s a summary of the key universal shared homologous epitopes recognized by T cells on these two viruses:
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1. Types of Shared Epitopes
Spike (S) Protein Epitopes:
The S protein is the most immunogenic viral protein. Certain conserved regions, especially in the S2 subunit (which facilitates membrane fusion), are more conserved across coronaviruses.
Example: Regions around heptad repeats (HR1, HR2) are relatively conserved in OC43 and SARS-CoV-2.
Nucleocapsid (N) Protein Epitopes:
The N protein is more conserved across coronaviruses than the S protein. T cells often recognize epitopes from the N protein due to its intracellular abundance and its role in viral RNA packaging.
Example: T cell responses have been identified against conserved N-terminal and C-terminal epitopes.
Membrane (M) and Envelope (E) Proteins:
Although the M and E proteins are smaller and less immunogenic, certain regions are highly conserved. They may serve as shared epitopes, but they are less well characterized compared to the S and N proteins.
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2. CD4+ and CD8+ T Cell Epitopes
CD4+ T cell Epitopes (presented on MHC class II)
Found in regions of S, N, and M proteins that are conserved across coronaviruses.
CD4+ T cells recognize peptides derived from extracellular or endosomal viral proteins.
CD8+ T cell Epitopes (presented on MHC class I)
Primarily derived from intracellular proteins like N protein and portions of the S protein.
Cross-reactive CD8+ T cell responses are frequently found in memory T cells of individuals with previous OC43 exposure, even if they never had COVID-19.
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3. Examples of Specific Shared Epitopes
S Protein Epitope (S816-S830):
Shared between SARS-CoV-2 and seasonal betacoronaviruses like OC43. T cells recognize it due to its role in membrane fusion.
N Protein Epitope (N105-N120):
A highly conserved T cell epitope found in both OC43 and SARS-CoV-2, capable of inducing strong CD8+ T cell responses.
M Protein Epitope (M50-M65):
While less studied, regions within the membrane protein show strong conservation and are predicted to be cross-reactive epitopes.
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4. How are These Epitopes Recognized?
Cross-reactive T Cell Immunity:
T cells specific to epitopes in OC43 can recognize the homologous epitopes in SARS-CoV-2. This may explain the presence of pre-existing immunity in people never exposed to SARS-CoV-2.
Memory T cells from prior infections with common cold coronaviruses like OC43 can be "recalled" upon infection with SARS-CoV-2.
Immunodominance:
Not all shared epitopes elicit strong immune responses. Some may be more "immunodominant" due to their better presentation on MHC molecules or higher availability.
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5. Implications for Immunity and Vaccination
Cross-reactive immunity may reduce disease severity of COVID-19 in people previously exposed to OC43 or other seasonal coronaviruses.
Understanding shared T cell epitopes could lead to the development of a pan-coronavirus vaccine targeting these conserved regions.
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If you'd like, I can provide a more detailed list of specific peptide sequences or references to studies identifying these epitopes.
Well he is wrong then, isn't he.
Memory T cells are in play stopping
People dying.
Cos if they weren't. You'd all be dead.
2. No such thing as a "sterilising CTL".
The memory T cells have been keeping most people safe this entire time. Just cos an entire planet of experts and doctors just "forgot" basic pre existing cross reactive T cell immunity, and the second half of the spike, doesn't mean they aren't and haven't been doing a great job this entire time .
May the judgment come sooner than later
Jews deceived all nations and caused so many sufferings, killings and blood rituals against children since the old times, read their Chronicles! Jews even disobeyed God and he punished them by sending them wandering for 40 years, then so peace for 40 years which makes 80 years then they will disappear. This is very clear in their TORAH and not their fake heinous Talmud, also it is in the Quran! Another point I disagree with is Hitler just like Mandela was classed a s terrorists yet he was freedom fighter for all Africans. I am African but not South African. Hitler stopped Jews pedophilia, theft, usury and monopolizing the bank and especially stopped the loans with extortionate interests which burdened the nation and the poor in Germany, that's what IMF is doing now. He closed ALL clubs and bars where gays and pedophiles were fornicating their sordid evil. Unfortunately, the West is controlled and brainwashed by the Zionist propaganda for decades.
Decades ago, Gustave Le Bon said: "The more educated people are, the more vulnerable they are for Mass Formation" and that's exactly what we saw in the West (Secular) who believe and worship (not God) but their governments which are made of these Elite Globalist and WEF Young Leaders. For years, I have been telling my Western friends that the Western government are looting us in Africa, they put puppets in charge of us who are paid tons of money to implement the West's EVIL agenda hence we never believed in our governments like the Westerners do. Told them about what Bill Gates of Hell was doing to African especially in the villages when his Evil Foundation were using us as guinea pigs since early 70's. Gates sterilized millions of women with Tetanus vaccines laced with HCG, then he injected many with HIV who almost all developed AIDS after 2 to 5 years and died because Bill Gated of HELL who gave many Africans the vaccines, wasn't going to give the cure for free, in fact, the price was so high, no one could afford it, therefore many died of AIDS. No to forget he jabbed Africans with Ebola and thousands died then he experimented with Korona vaccines and some children died but anyway, they still went ahead with it vaccinated the whole West who did not fear God or putting something into their bodied that was so quickly available from Big pharma that had so many lawsuits and payments like Pfizer. I could not believe what I was hearing and seen. At least in Africa, we might live under dictators put on us by the West but we do question everything and do refuse things without been punished or losing our jobs. We didn't have severe lockdowns either hence now we do not have Sudden Death, Long Covid or Myocarditis as you have in the West except for South Africa who injected so many of its citizens. The REAL enemy like Julian Assange said: "Forget Russia, forget China, the real enemy is Israel".
Both China and Russia have been in Africa just like USA, France, Germany, Netherlands etc but they have so far never killed anyone, never injected anyone, never invaded anyone and never looted in any African country, like the so called Western Civilized democracies! Russia and China have built bridges, roads, school, hospitals, dams and more. People in the West need to wake up and rise up against their own governments who are killing them, lying o them, taking to wars and implementing total control and depopulation under the gaze of WEF and WHO which still pushing for the WHO Pandemic Amendment and which 47 African countries rejected and saved the West and the World. However, this isn't the end of WHO Amendments as most of the WEST has signed up for it and other countries, they are cooking something soon in 2025! God help those who resist and do not consent. Truth Always Prevails and Evil can never Win!
Truth is dead and evil prevails. The devil is king, of this world.
I would imagine Africa’s population forecast isn’t grim in 2025 like most other countries are, according to Deagle!
Bunker dwellers,
Check out this article. Might as well entertain ourselves while we wait for the apocalypse...
https://open.substack.com/pub/casperstith/p/hey-stupid-its-the-cytotoxic-t-cells?r=39j5v8&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
Scientists baffled or think we’re total buffoons!! What utter nonsense!
Africa “winning” I find to be relative in this situation. I feel like those regions are in just as bad if not worse situations if the immune escape pans out. Mass death in other countries would significantly bring down trade and technological communication and other networks, and I’m one to assume the continent will descend into anarchy and famine to a point that a lot would die there also even if they aren’t as affected.
They are pointing to Democratic Republic of the Congo as a main candidate of next "disease X" origin.