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"Use of vaccines in the absence of the circulating target pathogen will not allow an individual or even an entire population to exert suboptimal immune pressure on the pathogen’s life cycle

However, as soon as the pathogen is circulating in a population, it becomes possible to put suboptimal immune pressure on its life cycle"

Please clarify: You said to not vaccinate into a pandemic. Now you say to not vaccinate before a pandemic. Maybe your point is implied? Only vaccinate when the pathogen is circulating in low volume? If so, that is a really small window of opportunity. Much more needs to be said about this.

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"Use of vaccines in the absence of the circulating target pathogen will not allow an individual or even an entire population to exert suboptimal immune pressure on the pathogen’s life cycle

However, as soon as the pathogen is circulating in a population, it becomes possible to put suboptimal immune pressure on its life cycle"

Please clarify: You said to not vaccinate into a pandemic. Now you say to not vaccinate before a pandemic. Maybe your point is implied? Only vaccinate when the pathogen is circulating in low volume? If so, that is a really small window of opportunity. Much more needs to be said about this.

Expand full comment