Within-host selection pressure does NOT dictate viral evolution and thus does not correlate with the emergence of SARS-CoV-2 variants in highly Covid-19 vaccinated populations.
Within-host selection pressure does NOT dictate viral evolution and thus does not correlate with the emergence of SARS-CoV-2 variants in highly Covid-19 vaccinated populations.
Contrary to the implications of this publication (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063955/), studying within-host diversity of SARS-CoV-2 (SC-2) may not always be a scientifically robust approach for investigating viral evolution, especially in the context of
Having followed your covid-related work since you first spoke out, I find your claims supported by all the research I've done.
It could be interesting: H5N1 seems determined to make a zoonotic breakout into humans and then become transmissible between humans, probably even this year, best I can tell. The future looks harsh. Your clarity and consistent message have been a real comfort to me even as the inevitable wave of lethal hard times looms on the horizon. https://www.youtube.com/watch?v=r57J0jPyZRs
Amidst so many bad actors I find comfort knowing that people like Geert, a very few, continue to investigate and are willing to stand up against the tide’s current regardless of the outcome because it is right to speak what we believe to be accurate and true.
In 100 years, when everyone here will be gone regardless of the outcome of the current Covid theater, some will have lived bravely speaking truth, which I believe may resonate throughout the cosmos in some mysterious way.
Thank u GVB …. I understand immune escape and variants, how about a conversation regarding all the side effects such as miscarriages, placental abruptions , stillbirths,heart issues auto immune diseases, turbo cancers ect
KP.2 variant is doing what Philip McMillan predicted and could be the predecessor of HIVICRON. At least that's what I read into it. Please see for yourself:
I will go off topic to make a comparison: entities like, for example, the USA milindustriao coimplex are like a vaccine factory to protect USNATO/Euromerican prosperity and greed by exporting violence abroad to enforce our will. It is as if the world were a disease that Euromerica must fight in order to survive.
But the indiscriminate and incompetent misapplication of what should be national defense (not global offense) has created a growing population of geopolitical international variants increasingly immune to our weapons/foreign policy/economic clout etc. The Euromerican milindustrial complex is experiencing increasing selection pressure from which it cannot escape except by become transinfectious and turning the milindustrial complex against Euromerica.
Geopolitically, in all forms from warfare to economy, Euromerica is entering its own sociopolitical HIVICRON phase. Entuire nations will cease to exist, especially with Geert's predicted HIVICRON showing on the near horizon.
This guy -- https://harvard2thebighouse.substack.com/p/understanding-covid-19-and-seasonal --does a good if somewhat scattered job of explaining mutant swarm quasi-species and how they work under certain conditions to create HIVICRON-like super-spreading highly toxic viral variants. A bit sdcattered, like I said, but also very entertaining and packed with lots of relevant history.
"The population-level immune selection pressure on the virus persists as long as herd immunity is not achieved." GVB
These are dire predictions as it will imply constant re-infection with emergent VBTI in both vaccinated and unvaccinated individuals until population-level immunity reach herd immunity level.
To me the big question is if most of the highly vaccinated (with a varying degree of depleted immune-apparatus) will have to succumb to different VBTI before this state of herd immunity is obtained, or does our immune-apparatus have hitherto unrecognized tools in its basket?
Interestingly, within the literature of within-host diversity measurement, there is also this paper; https://www.cell.com/iscience/fulltext/S2589-0042(22)01710-2 ; that shows “ A deep analysis revealed a significantly higher intra-host diversity in Omicron samples than in other variants (p value < 0.05). Vaccination status and type had a limited impact on intra-host diversity except for Beta-B.1.315 and Delta-B.1.617.2 vaccinees, who exhibited higher diversity than unvaccinated individuals (p values: <0.0001 and <0.0021, respectively). Three immune-escape mutations were identified: S255F in Delta and R346K and T376A in Omicron-B.1.1.529. The latter 2 mutations were fixed in BA.1 and BA.2 genomes, respectively.”. So it appears that in some instances, vaccination can have with little or more impact depending upon the mutations selected.
> vaccine breakthrough infections (VBTIs), such as those caused by Omicron
This is a wrong statement - in the light of other statements by professionals speaking out. The sequence of events is said to be just the opposite to this statement. Omicron does not cause breakthrough infections. It cannot cause them, which is clear even from the name used: “vaccine breakthrough infection” means vaccine failure.
Ineffective vaccine contributes to or causes breakthrough infections, not a particular mix of viruses. “Breakthrough” means “in spite of the applied measures” - at least this is what the public was told.
Are we now rewriting these definitions and explanations of mechanisms?
Thanks for sharing this timely update and information Dr Bossche much appreciated 🙏
Having followed your covid-related work since you first spoke out, I find your claims supported by all the research I've done.
It could be interesting: H5N1 seems determined to make a zoonotic breakout into humans and then become transmissible between humans, probably even this year, best I can tell. The future looks harsh. Your clarity and consistent message have been a real comfort to me even as the inevitable wave of lethal hard times looms on the horizon. https://www.youtube.com/watch?v=r57J0jPyZRs
Maybe the 20,000,000 illegal immigrants will bring heard immunity to the USA.
Amidst so many bad actors I find comfort knowing that people like Geert, a very few, continue to investigate and are willing to stand up against the tide’s current regardless of the outcome because it is right to speak what we believe to be accurate and true.
In 100 years, when everyone here will be gone regardless of the outcome of the current Covid theater, some will have lived bravely speaking truth, which I believe may resonate throughout the cosmos in some mysterious way.
Thank u GVB …. I understand immune escape and variants, how about a conversation regarding all the side effects such as miscarriages, placental abruptions , stillbirths,heart issues auto immune diseases, turbo cancers ect
.
Most Doctors
Enjoy Being Proven Wrong
Far Less
Than They Tolerate Killing You.
.
All variant analysis must appreciate the reality of bioweapon lab viral "evolution".
are 'bird flu' and 'disease x' cover for what's to come to the vaxxed?
what explains this new "global cancer phenomenon"... https://eccentrik.substack.com/p/global-cancer-phenomenon-the-multi?utm_campaign=comment&utm_medium=email&utm_source=substack&utm_content=post
KP.2 variant is doing what Philip McMillan predicted and could be the predecessor of HIVICRON. At least that's what I read into it. Please see for yourself:
https://www.thailandmedical.news/news/study-identifies-virological-characteristics-of-the-sars-cov-2-kp-2-variant-one-of-the-variants-behind-spring-s-silent-covid-19-surge
Having demonstrated that I am both a ham and a big mouth, I'll close today's graphomania with a song:
https://youtu.be/EPioMUr4ZM4
Some say the world is spinning faster
Some say it isn't fast enough
Some people say they've got the answer
And some are scared to say they can't keep up
I read the paper but it still isn't clear
The bombs are falling but I'm still here
I know all the figures and I know all the facts
But all I can do is keep trying...
To look for the human touch
Life is hard when you've got nothing
Life can be hard when you've got too much
Sometimes I wonder what's the difference
It's only better with someone to touch
I got the telephone stuck to my ear
I keep yelling but you don't hear
In all the universe I'm just a speck of dust
But all I can do is keep trying...
To give you the human touch
You know we're nothing in the scheme of things
Just microchips in big machines
And the world is spinning round and round
But I know that we can slow it down
And I know that I can make you see
I'm on the side of you and me
And all I want to do
Listen to me...
Is give you...give you
Give you the human touch
I was sick several years ago with H1N1. It was the sickest I'd ever been in my life. Hopefully it gives me some immunity to the new bird flus.
I will go off topic to make a comparison: entities like, for example, the USA milindustriao coimplex are like a vaccine factory to protect USNATO/Euromerican prosperity and greed by exporting violence abroad to enforce our will. It is as if the world were a disease that Euromerica must fight in order to survive.
But the indiscriminate and incompetent misapplication of what should be national defense (not global offense) has created a growing population of geopolitical international variants increasingly immune to our weapons/foreign policy/economic clout etc. The Euromerican milindustrial complex is experiencing increasing selection pressure from which it cannot escape except by become transinfectious and turning the milindustrial complex against Euromerica.
Geopolitically, in all forms from warfare to economy, Euromerica is entering its own sociopolitical HIVICRON phase. Entuire nations will cease to exist, especially with Geert's predicted HIVICRON showing on the near horizon.
Moral: global vaccination plans are dicey.
This guy -- https://harvard2thebighouse.substack.com/p/understanding-covid-19-and-seasonal --does a good if somewhat scattered job of explaining mutant swarm quasi-species and how they work under certain conditions to create HIVICRON-like super-spreading highly toxic viral variants. A bit sdcattered, like I said, but also very entertaining and packed with lots of relevant history.
"The population-level immune selection pressure on the virus persists as long as herd immunity is not achieved." GVB
These are dire predictions as it will imply constant re-infection with emergent VBTI in both vaccinated and unvaccinated individuals until population-level immunity reach herd immunity level.
To me the big question is if most of the highly vaccinated (with a varying degree of depleted immune-apparatus) will have to succumb to different VBTI before this state of herd immunity is obtained, or does our immune-apparatus have hitherto unrecognized tools in its basket?
Interestingly, within the literature of within-host diversity measurement, there is also this paper; https://www.cell.com/iscience/fulltext/S2589-0042(22)01710-2 ; that shows “ A deep analysis revealed a significantly higher intra-host diversity in Omicron samples than in other variants (p value < 0.05). Vaccination status and type had a limited impact on intra-host diversity except for Beta-B.1.315 and Delta-B.1.617.2 vaccinees, who exhibited higher diversity than unvaccinated individuals (p values: <0.0001 and <0.0021, respectively). Three immune-escape mutations were identified: S255F in Delta and R346K and T376A in Omicron-B.1.1.529. The latter 2 mutations were fixed in BA.1 and BA.2 genomes, respectively.”. So it appears that in some instances, vaccination can have with little or more impact depending upon the mutations selected.
> vaccine breakthrough infections (VBTIs), such as those caused by Omicron
This is a wrong statement - in the light of other statements by professionals speaking out. The sequence of events is said to be just the opposite to this statement. Omicron does not cause breakthrough infections. It cannot cause them, which is clear even from the name used: “vaccine breakthrough infection” means vaccine failure.
Ineffective vaccine contributes to or causes breakthrough infections, not a particular mix of viruses. “Breakthrough” means “in spite of the applied measures” - at least this is what the public was told.
Are we now rewriting these definitions and explanations of mechanisms?