I'm no immunologist but I don't think Omicron has mutated to a point that S-antibodies will not recognize it. Remember that SARS1 antibodies recognized SARS-CoV2 and there was only a 70% similarity. Even with these 30+ mutations, Omicron is still way over 90% in similarity to Delta. The problem is that the S-antibodies do not work well a…
I'm no immunologist but I don't think Omicron has mutated to a point that S-antibodies will not recognize it. Remember that SARS1 antibodies recognized SARS-CoV2 and there was only a 70% similarity. Even with these 30+ mutations, Omicron is still way over 90% in similarity to Delta. The problem is that the S-antibodies do not work well against Omicron but still get produced. This is Original Antigenic Sin. Would be interested to hear Geert's views on OAS as a possible outcome.
Does "S-antibodies can no longer *outcompete* innate immune system" equal "not *recognize* the spike protein?"
I was thinking specifically of this statement:
"By evolving more and more resistance to S-directed, neutralizing antibodies (Abs), SARS-CoV-2 is increasingly setting free the host’s innate Abs (as they’re no longer suppressed)."
It is the vaxxed who's innate Abs have been suppressed, not the unvaxxed. So I think Geert is referring to vaxxed hosts here, & is hinting at an off-ra p for them. His next article seems to affirm this.
I think he has always considered OAS as a likely outcome. This is the 1st ray of hope I have seen from him.
That said, I think its too soon, by a few weeks, to be sure what is going on. US & Euro populations are very different from SA, in terms of vax levels & overweight/comorbidities. It may lose its "mildness* when it hits our vaxxed pop.
I'm no immunologist but I don't think Omicron has mutated to a point that S-antibodies will not recognize it. Remember that SARS1 antibodies recognized SARS-CoV2 and there was only a 70% similarity. Even with these 30+ mutations, Omicron is still way over 90% in similarity to Delta. The problem is that the S-antibodies do not work well against Omicron but still get produced. This is Original Antigenic Sin. Would be interested to hear Geert's views on OAS as a possible outcome.
Lol, I'm not an immunologist either.
Does "S-antibodies can no longer *outcompete* innate immune system" equal "not *recognize* the spike protein?"
I was thinking specifically of this statement:
"By evolving more and more resistance to S-directed, neutralizing antibodies (Abs), SARS-CoV-2 is increasingly setting free the host’s innate Abs (as they’re no longer suppressed)."
It is the vaxxed who's innate Abs have been suppressed, not the unvaxxed. So I think Geert is referring to vaxxed hosts here, & is hinting at an off-ra p for them. His next article seems to affirm this.
I think he has always considered OAS as a likely outcome. This is the 1st ray of hope I have seen from him.
That said, I think its too soon, by a few weeks, to be sure what is going on. US & Euro populations are very different from SA, in terms of vax levels & overweight/comorbidities. It may lose its "mildness* when it hits our vaxxed pop.