Voice for Science and Solidarity by Geert Vanden Bossche

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Q&A #19 : Some questions from a good friend
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Q&A #19 : Some questions from a good friend

Geert Vanden Bossche
Jul 19
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Q&A #19 : Some questions from a good friend
voiceforscienceandsolidarity.substack.com

Q 1

‍What are the mechanism(s) that (largely) bypass the innate immune system upon vaccination with non-replicating vaccines (like mRNA)?  Is this simply because it is a localized injection that doesn't replicate/spread throughout other tissues and organs? Or is this due to additives in mRNA vaccines that prevent innate immune stimulation in order for the mRNA itself to not be degraded before being absorbed into target cells?

A 1

‍Only replicating virus will present virus-derived (self-mimicking)motifs/patterns (on the surface of infected cells) that can be recognized by innate effector cells (NK cells).

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‍Q 2

‍Why does C19 vaccination in young children prevent training of their innate immune systems for recognizing other viruses that they would later encounter? I understand how specific Abs can outcompete innate antibodies for a given virus, but why would specific Abs for SARS-CoV-2 Spike outcompete innate antibodies for something like influenza?

A 2

‍Because innate Abs bind to all glycosylated viruses. Although innate Abs can recognize a myriad of viruses, these very same viruses will require (self-mimicking) pattern recognition by NK cells to be recognized later on. It is through this pattern recognition mechanism that NK cells can be trained more specifically for the pattern presented by a particular virus (but which has reasonable homology with self-mimicking patterns presented by other glycosylated viruses).


‍Q 3

‍Can you elaborate on this pattern recognition?

A 3

‍Innate Abs are typically polyspecific! They recognize self-like surface-expressed sugar patterns. In the case of enveloped glycosylated viruses, those are of course derived from the infected host cells (which provide the envelope of the virus!). This is why these sugar patterns are broadly shared amongst glycosylated viruses.

Thanks for reading Voice for Science and Solidarity by Geert Vanden Bossche! Subscribe for free to receive new posts and support my work.

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Q&A #19 : Some questions from a good friend
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Rosemary B
Jul 19

Thank you Dr Geert for sharing this. What a wonderful explanation.

I wish I could share this information with my kids as they are parents now.

They are rejecting any and all information that I provide to them and as of this day

I am "banned" by my youngest daughter's husband, from visiting or engaging with the grand children. We live in a dystopian world

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Brandon is not your bro
Jul 19

Dr.Vanden Bossche, Very grateful for these explanations. We haven’t had grand rounds in our hospital in the last few years due to Covid crap. Very little intelligent discussions with any medical staff. I am starved for information and discussions. Thank you !!

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