Case rates as published by UK Health Security Agency (previous PHE) strongly suggest that the more innate antibodies (Abs) are trained, the more they resist competition from either poorly functional anti-S(pike) Abs generated from asymptomatic/ mild infection (in the unvaccinated), or from vaccinal Abs (in the vaccinated). This explains why the effect of immunosuppressive, poorly functional anti-S Abs on promoting disease (i.e., on breaking through innate immunity) in the unvaccinated as well as the effect of functional, vaccine-induced anti-S Abs on preventing disease in vaccinees is most pronounced in
Ah, this is interesting. The official explanation for the discrepancy you describe here shown in the recent data from the U.K. seems to be that the populations who were most recently jabbed (2 shot regimen or boosted) are least likely to suffer breakthrough infections. If I understand you correctly, you are saying these "vaccines" are most effective in preventing covid in those whose innate immune systems are the least trained. But this is precisely the population in whom we should not be trying to prevent covid.
This reminds me of insights from "On interventionistas and their mental defects" by Nassim Nicholas Taleb:
1. "Complex systems do not have an obvious one-dimensional cause and effects mechanisms, and that under opacity, you do not mess with such a system";
2. "One should not mess with a system if the results are fraught with uncertainty, or, more generally, avoid engaging in an action if you have no idea of the outcomes".
3. "Those who don’t take risks should never be involved in making decisions."
This is an excellent summary of the true nature of the vaccination problem that often gets overlooked when we think about risk. Just the possibility that this might be true means any reasonable benefit risk analysis does not pass the sniff test.
Would using prophylactic Ivermectin prevent infection by Sars-CoV-2 and the development of natural immunity or would it be better to wait and institute early treatment with IVM if infection occurs?Thank you GVB for all you are doing.
One thing I would find useful is more discussion of the notion of "training" the innate immune system. I take it that the distinction between innate and adaptive immune systems is not as clean as the terms would suggest, given that presumably "training" of the innate immune system is itself a form of adaptation?
Can you explain here this statement: "...the deployment of mass vaccination with updated vaccines that match the antigenic constellation of Omicron’s S protein ...unleashing a tsunami of severe disease and death". The link to ref. 2 does not work. Will it be because of OAS? Or the mRNA jab adverse reactions? Thanks!
Wow-😲 "This will likely entail waves of more serious disease in vaccinees and, sadly, prompt the deployment of mass vaccination with updated vaccines that match the antigenic constellation of Omicron’s S protein. I’ve already warned that such an unfortunate decision will be at risk of unleashing a tsunami of severe disease and death (2), primarily in vaccinated children and those who’ve been vaccinated before their innate Ab-secreting B cells acquired sufficient CoV experience)"
B. Innate antibodies generated from prior infections.
C. Vaccine induced antibodies.
2. Anti-S Abs generated from asymptomatic/mild infection create immature antibodies which also suppress the immune system.
3.Children have immature immune systems which can be trained more readily. Meaning they generate antibodies more readily but they have a more focused immune system subsequently.
4. Try ignoring the bracketed words in complex sentences.
Geert, can you kindly provide some references to evidence the existence of "poorly functional anti-S(pike) Abs generated from asymptomatic/ mild infection"? I am really struggling to find this concept in the literature. I have asked an immunologist (and vaccine developer) from a renownedacademic institution who says he knows no such phenomenon.
Hard to read this. Please split into smaller paragraphs. I didn't see the bigger conclusion: Vaccinees will be the breeding ground for the next very pathogenic variant after this Omicron which may have been released by China to provide cover, thinking it will build herd immunity. How did Omicron go into Deep Freeze then suddenly appear?
I really want to understand this. Is there a commenter who can do a "Geert Vanden Bossche For Dummies" (English major) translation for me. Thanks!
I really wish you would put a paragraph explaining this in layman's terms so we know what you are saying? I'm completely lost by the 2nd paragraph. :(
Okay lets read this again and again.
Ah, this is interesting. The official explanation for the discrepancy you describe here shown in the recent data from the U.K. seems to be that the populations who were most recently jabbed (2 shot regimen or boosted) are least likely to suffer breakthrough infections. If I understand you correctly, you are saying these "vaccines" are most effective in preventing covid in those whose innate immune systems are the least trained. But this is precisely the population in whom we should not be trying to prevent covid.
This reminds me of insights from "On interventionistas and their mental defects" by Nassim Nicholas Taleb:
1. "Complex systems do not have an obvious one-dimensional cause and effects mechanisms, and that under opacity, you do not mess with such a system";
2. "One should not mess with a system if the results are fraught with uncertainty, or, more generally, avoid engaging in an action if you have no idea of the outcomes".
3. "Those who don’t take risks should never be involved in making decisions."
https://medium.com/incerto/on-neo-cons-and-their-mental-defects-d12685585b11
This is an excellent summary of the true nature of the vaccination problem that often gets overlooked when we think about risk. Just the possibility that this might be true means any reasonable benefit risk analysis does not pass the sniff test.
Would using prophylactic Ivermectin prevent infection by Sars-CoV-2 and the development of natural immunity or would it be better to wait and institute early treatment with IVM if infection occurs?Thank you GVB for all you are doing.
Does this mean all the vaxxed children are doomed?
The diagrams aren't showing up here (yet?) but I was able to find them at the link.
One thing I would find useful is more discussion of the notion of "training" the innate immune system. I take it that the distinction between innate and adaptive immune systems is not as clean as the terms would suggest, given that presumably "training" of the innate immune system is itself a form of adaptation?
Dear Dr. vanden Bosche,
Can you explain here this statement: "...the deployment of mass vaccination with updated vaccines that match the antigenic constellation of Omicron’s S protein ...unleashing a tsunami of severe disease and death". The link to ref. 2 does not work. Will it be because of OAS? Or the mRNA jab adverse reactions? Thanks!
Wow-😲 "This will likely entail waves of more serious disease in vaccinees and, sadly, prompt the deployment of mass vaccination with updated vaccines that match the antigenic constellation of Omicron’s S protein. I’ve already warned that such an unfortunate decision will be at risk of unleashing a tsunami of severe disease and death (2), primarily in vaccinated children and those who’ve been vaccinated before their innate Ab-secreting B cells acquired sufficient CoV experience)"
Some tips. (Not sure if right.)
1. There are 3 types of anti bodies.
A. Short lived abs from mild infections.
B. Innate antibodies generated from prior infections.
C. Vaccine induced antibodies.
2. Anti-S Abs generated from asymptomatic/mild infection create immature antibodies which also suppress the immune system.
3.Children have immature immune systems which can be trained more readily. Meaning they generate antibodies more readily but they have a more focused immune system subsequently.
4. Try ignoring the bracketed words in complex sentences.
Both of the reference links are not working
Geert, can you kindly provide some references to evidence the existence of "poorly functional anti-S(pike) Abs generated from asymptomatic/ mild infection"? I am really struggling to find this concept in the literature. I have asked an immunologist (and vaccine developer) from a renownedacademic institution who says he knows no such phenomenon.
Hard to read this. Please split into smaller paragraphs. I didn't see the bigger conclusion: Vaccinees will be the breeding ground for the next very pathogenic variant after this Omicron which may have been released by China to provide cover, thinking it will build herd immunity. How did Omicron go into Deep Freeze then suddenly appear?