My bible on the C-19 mass vaccination experiment. Nobody can conceal a scourge that Nature is now desperate to unveil. Summary The cell-based innate immune system (CBIIS) is critically important for removal of most of the SARS-CoV-2 (SC-2) viral load upon primary infection and even re-infection (as infection-primed antibodies decline quite rapidly). Training of the CBIIS (i.e., comprising adaptation and functional reprogramming of innate Natural Killer [NK] cells via epigenetic imprinting) may even obviate the need for engaging the adaptive immune system. Population-level immune pressure on viral infectiousness following mass vaccination with S(pike) protein-directed C-19 vaccines during a pandemic eventually sidelines this vitally important first line of immune defense against SC-2. As large-scale suboptimal humoral immune pressure on viral infectiousness drives natural selection and expansion of immune escape variants that the C-19 vaccine-induced antibodies (Abs) cannot sufficiently neutralize, infection-enhancing polyreactive, non-neutralizing Abs (PNNAbs) come into effect and cause PNNAb-dependent enhancement of viral infectiousness. Omicron became the first dominantly circulating SC-2 variant that managed to cause large-scale PNNAb-dependent breakthrough infections in highly vaccinated populations.
My bible on the C-19 mass vaccination…
My bible on the C-19 mass vaccination experiment. Nobody can conceal a scourge that Nature is now desperate to unveil. Summary The cell-based innate immune system (CBIIS) is critically important for removal of most of the SARS-CoV-2 (SC-2) viral load upon primary infection and even re-infection (as infection-primed antibodies decline quite rapidly). Training of the CBIIS (i.e., comprising adaptation and functional reprogramming of innate Natural Killer [NK] cells via epigenetic imprinting) may even obviate the need for engaging the adaptive immune system. Population-level immune pressure on viral infectiousness following mass vaccination with S(pike) protein-directed C-19 vaccines during a pandemic eventually sidelines this vitally important first line of immune defense against SC-2. As large-scale suboptimal humoral immune pressure on viral infectiousness drives natural selection and expansion of immune escape variants that the C-19 vaccine-induced antibodies (Abs) cannot sufficiently neutralize, infection-enhancing polyreactive, non-neutralizing Abs (PNNAbs) come into effect and cause PNNAb-dependent enhancement of viral infectiousness. Omicron became the first dominantly circulating SC-2 variant that managed to cause large-scale PNNAb-dependent breakthrough infections in highly vaccinated populations.