We keep being flooded with exciting news about the magic contribution of T cells to preventing disease or avoiding progression to severe disease (https://www.nature.com/articles/d41586-022-00063-0: ‘Killer’ immune cells still recognize Omicron variant). Given the caliber and reputation of the scientists authoring these publications, one would almost end up believing that T cells are, indeed, doing the trick! However, the interpretation of these data is highly questionable. There is now a plethora of publications that strongly suggest a potential role of SARS-CoV-2-reactive memory T cells in abrogating SARS-CoV-2 infection and preventing Covid-19 disease. However, the authors of these papers don’t seem to feel the need for distinguishing between T cell-mediated cross-reactivity / cross recognition and cross-protection. There is no proof, however, that cross-reactive SARS-CoV-2 memory T cells can abrogate infection and prevent Covid-19 disease
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