How often have I said to you that when you have eliminated the impossible, whatever remains, however improbable, must be the truth?

How often have I said to you that when you have eliminated the impossible, whatever remains, however improbable, must be the truth? (Arthur Conan Doyle, The Case-Book of Sherlock Holmes)

People are rightfully concerned, some even outraged, by my predictions of how this Covid-19 pandemic will end. Understandably, some also blame me for the timeline I proposed not being accurate. Of course, not everyone understands that the interplay between the virus/pathogen and the host population's immunity is complex and constantly determined by the pressure exerted by the population's adaptive immunity on the virus and the virus's adaptation to the changing immune environment. This game of cat and mouse continues because highly Covid-19 (C-19) vaccinated populations cannot develop herd immunity.

What we will eventually observe is that this highly effective process of viral adaptation will ultimately confer an absolute fitness advantage to a Coronavirus (CoV) that is both structurally and functionally completely different from SARS-CoV-2 (SC-2) and its variants. It will be featured by many changes in spike and other viral proteins and have additional O-glycosylation sites while being resistant to neutralizing antibodies (Abs), virulent and highly productive/ replicative. It will use polyreactive nonneutralizing Abs (PNNAbs) to cause Ab-dependent enhancement of infection, thereby causing enhancement of severe disease (basically, as a result of rapid virus dissemination and replication in all organs). It will spread as a ‘strange’ but dominating lineage as a kind of ‘extraterrestrial dictator’ that outcompetes all previously circulating SC-2 lineages.

The ongoing phenomenon of immune escape runs parallel to the increasing incidence of acute (IgG4 Ab-mediated) and chronic (CD8+ T cell-mediated) immune pathology (including cancers), both of which stem from dysregulation of the adaptive immune system in C-19 vaccine recipients.

The unvaccinated individuals who are in good health and have not previously suffered from severe C-19 disease will not be affected by this new CoV (I call it ‘HIVICRON’: a highly virulent CoV that will replace the entire Omicron family). This is because, unlike those who are fully C-19 vaccinated, they have managed to train their cell-mediated innate immunity through exposure to increasingly infectious variants (through epigenetic reprogramming).

As the immune escape pandemic will transition from its ‘chronic’ phase (i.e., characterized by a high prevalence of ‘Long COVID’!) to its final, hyperacute stage, we will observe a reduction in circulating Omicron descendants, and cryptic lineages will become increasingly undetectable in wastewater. Despite low virus concentrations in wastewater and low C-19 hospitalization and C-19 mortality rates, cases of Long COVID will continue to steadily increase. Given the insidious nature of the current evolution, I am referring to the current period as 'the calm before the tsunami’ and warning that ‘societies in highly C-19 vaccinated countries will be caught off guard’.

Those who naively believe that the pandemic will simply die out without major casualties or will be controlled by regular (updated) vaccine booster doses fail to grasp that it is no longer the C-19 vaccination itself but rather the recurrent vaccine breakthrough infections (even if largely asymptomatic in terms of acute C-19 disease!), initiated by Omicron as a result of mass vaccination (hence why Omicron has been a scourge, not a blessing!), that are fueling the progression of viral immune escape and immune pathology.

In other words, neither an extended period of vaccine abstention nor a recently updated shot will affect the remaining evolutionary trajectory of this immune escape pandemic (Hence the title of my book: ‘The Inescapable Immune Escape Pandemic’).

I can't help but conclude that all pieces of the puzzle are fitting nicely together and that the science behind all this is undeniably compelling. My analysis is the result of a thorough, prolonged, and painstaking exercise in deep diving into these matters, leaving no stone unturned. My journey through this pandemic has been quite different from that of our health authorities, so-called health experts, and leading scientists. To summarize the mess they have made of it, I prefer to use a quote from a good friend: “They have been throwing shit against a wall to see what sticks”! Some of that shit did indeed stick to the wall at the very beginning of the C-19 mass vaccination campaign, but then dripped off, first as watery diarrhea, then as pure bloody diarrhea…

I seriously doubt the stakeholders of this mass vaccination program were clever enough to realize that their ‘shit’ experiment would quickly emerge as the most spectacular gain-of-function experiment ever conducted in the history of biology (one that was directly conducted on our very own human species!!!). Whether intentional or not, I won't judge. The fact remains that soon it will become evident how, due to their actions, a fairly harmless virus was transformed into a bioweapon of mass destruction.

There is no greater impotence in all the world like knowing you are right and that the wave of the world is wrong, yet the wave crashes upon you. – Norman Mailer