Poor insights on what stimulates long-lived antibody production could spur false hope for better Covid-19 vaccines….

I had sworn to withdraw from social media due to all the superficiality, but some of my followers keep asking for my opinion regarding the interpretation of certain new publications, such as the one mentioned under

https://emea01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.science.org%2Fcontent%2Farticle%2Fmissing-immune-cells-may-explain-why-covid-19-vaccine-protection-quickly-wanes&data=05%7C02%7C%7C00a58ad641804f3072ce08dced9dc74e%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C638646509106023111%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=hq1q15l0hH7xWFIDDZaZed%2FP8Jf4d%2BX3NeMHVpT6zwE%3D&reserved=0

I am disgusted by the simplistic interpretation of several immunological phenomena by dogma-traumatized scientists. For example, this article suggests that the absence of long-lived plasma cells (LLPCs) is due to the fact that the distance between two neighboring spike (S) proteins is too large to allow crosslinking by receptors on B cells. As if S proteins were grafted onto a rigid membrane at a specific distance from each other!! Have these scientists never heard that cell membranes, and therefore also virus membranes of enveloped viruses, are fluid and that the proteins anchored in them can move to come closer together or move further apart?

It is now known and repeatedly documented that mRNA vaccines do not lead to the maturation of fully functional and long-lived IgG1 antibodies (Abs) after the second injection. As described in my book (https://bit.ly/3NYokkE), mRNA vaccines lead to immune refocusing, where suboptimal Abs are induced against immune subdominant or immune-recessive epitopes on the S protein. That this unnatural and weak, aberrant stimulation of the adaptive immune system does not induce LLPCs specific to SARS-CoV-2 (SC-2) is therefore logical.

The fact that LLPCs specific to SC-2 are also barely detectable in unvaccinated individuals who have had one or more SC-2 infections, however, has a completely different reason. The innate immune system of healthy, unvaccinated individuals is usually able to control the virus to a large extent, so that only weak stimulation of the adaptive immune system is required to finally eliminate the virus. This was certainly the case at the beginning of the pandemic when the circulating lineages were still relatively low in infectiousness. However, as the immune escape pandemic continued to evolve and the innate immune system of the unvaccinated became better and better trained, the contribution of their adaptive immune system to controlling the virus remained relatively minor. Consequently, immunological memory was barely triggered; in any case, not sufficiently to generate significant amounts of LLPCs specific to SC-2.

Last, even though Covid-19 (C-19) vaccines based on virus-like particles (VLPs) may improve the immunogenicity of the S protein, the catastrophic failure of the C-19 mass vaccination program is not due to the poor quality or longevity of anti-S Abs, but rather to the fact that large-scale immunization. campaigns during the pandemic drove viral immune escape, turning the natural pandemic into an artificial immune escape pandemic.